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the claim

Calcium influx triggers the exocytosis of mast cell secretory granules.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that calcium influx triggers the exocytosis of mast cell secretory granules?

Yes. Multiple studies demonstrate that calcium influx and mobilization play a critical role in triggering the exocytosis of secretory granules in mast cells.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The analysis

The retrieved literature contains multiple direct studies (such as direct microinjection of calcium and calcium ionophore experiments) and molecular analyses showing that calcium influx is a key trigger for mast cell degranulation. There is no contradictory evidence in the provided papers.

Evidence for · 5
Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms
2008
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Puri, N. & Roche, P. A. (2008). Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms. doi.org. https://doi.org/10.1073/pnas.0707854105

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More for · 4
Cdc42 and Rac Stimulate Exocytosis of Secretory Granules by Activating the Ip3/Calcium Pathway in Rbl-2h3 Mast Cells
2000
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Hong-Geller, E. & Cerione, R. A. (2000). Cdc42 and Rac Stimulate Exocytosis of Secretory Granules by Activating the Ip3/Calcium Pathway in Rbl-2h3 Mast Cells. doi.org. https://doi.org/10.1083/jcb.148.3.481

Exocytosis (Secretory Granule Extrusion) Induced by Injection of Calcium into Mast Cells
1973
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Kanno, T., Cochrane, D. E., & Douglas, W. W. (1973). Exocytosis (Secretory Granule Extrusion) Induced by Injection of Calcium into Mast Cells. doi.org. https://doi.org/10.1139/y73-153

Differential Regulation of Granule Release in Platelets and Immune Cells.
2026
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Q, X., J, H., H, S., Z, Z., & W, J. (2026). Differential Regulation of Granule Release in Platelets and Immune Cells.. doi.org. https://doi.org/10.1055/a-2885-2208

IKK2, calcium, MAP kinase, and PI3 kinase are required for exocytosis and interleukin-8 production in human mast cells stimulated by Trichomonas vaginalis-derived secretory products.
2026
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SH, P., YA, L., & MH, S. (2026). IKK2, calcium, MAP kinase, and PI3 kinase are required for exocytosis and interleukin-8 production in human mast cells stimulated by Trichomonas vaginalis-derived secretory products.. doi.org. https://doi.org/10.3347/phd.25079

What does the evidence say?

The retrieved literature contains multiple direct studies (such as direct microinjection of calcium and calcium ionophore experiments) and molecular analyses showing that calcium influx is a key trigger for mast cell degranulation. There is no contradictory evidence in the provided papers.

Receipt History
first checked06 Aug 2026
judged → SUPPORTED · 8906 Aug 2026
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