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the claim

Biological immortality is strictly speaking impossible due to thermodynamic constraints

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that biological immortality is strictly speaking impossible due to thermodynamic constraints?

Yes. Biological aging and the limits of longevity are governed by thermodynamic constraints, specifically entropy production and information loss, which theoretical and empirical models indicate make biological immortality unachievable.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The analysis

The retrieved papers consistently support the thermodynamic perspective on aging and life spans. Papers like [6] and [9] explicitly link thermodynamic biological age and entropy production to the limits of age reversal and the impossibility of halting the aging drift. Papers [2], [4], and [10] provide the broader thermodynamic context of living systems maintaining non-equilibrium states. None of the papers refute the claim.

Evidence for · 5
Life’s a Gas: A Thermodynamic Theory of Biological Evolution
2015
The paper uses thermodynamic principles and entropy production to frame biological evolution and the inevitable dynamics of living systems.
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Skene, K. (2015). Life’s a Gas: A Thermodynamic Theory of Biological Evolution. doi.org. https://doi.org/10.3390/e17085522

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More for · 4
Information dynamics in living systems: prokaryotes, eukaryotes, and cancer.
2011
It models living systems as maintaining stable entropy far from equilibrium, governed by energy costs and information constraints.
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BR, F. & RA, G. (2011). Information dynamics in living systems: prokaryotes, eukaryotes, and cancer.. doi.org. https://doi.org/10.1371/journal.pone.0022085

Aging clocks, entropy, and the limits of age-reversal
2022
It connects aging directly to thermodynamic biological age, tracking entropy production and information loss which sets limits on age-reversal.
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Tarkhov, A., Denisov, K., & Fedichev, P. (2022). Aging clocks, entropy, and the limits of age-reversal. doi.org. https://doi.org/10.1101/2022.02.06.479300

Aging Clocks, Entropy, and the Challenge of Age Reversal
2024
It demonstrates that thermodynamic constraints and entropy production during aging drive irreversible drift, constraining the possibility of complete age reversal.
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Tarkhov, A., Denisov, K., & Fedichev, P. O. (2024). Aging Clocks, Entropy, and the Challenge of Age Reversal. doi.org. https://doi.org/10.59368/agingbio.20240031

Thermodynamic Theory of Biological Evolution and Aging. Experimental Confirmation of Theory
1999
It confirms a thermodynamic theory of biological evolution and aging based on the second law of thermodynamics.
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Gladyshev, G. P. (1999). Thermodynamic Theory of Biological Evolution and Aging. Experimental Confirmation of Theory. doi.org. https://doi.org/10.3390/e1040055

Receipt History
first checked06 Aug 2026
judged → SUPPORTED · 8606 Aug 2026
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