Biological, genetic, and chromosomal incompatibilities—such as X-linked hybrid sterility and rapid genomic divergence—impose strong barriers that prevent successful and frequent hybridization among cat species.
The retrieved literature consistently supports the claim that genetic and chromosomal mechanisms create strong reproductive isolation barriers in felids. Papers [1], [2], [3], and [4] specifically detail the genetic underpinnings of hybrid male sterility, chromosomal structural variations, macrosatellite divergence, and genetic distance proxies that explain why cat hybrids face severe biological barriers. There are no papers refuting the claim.