Astronauts aboard the International Space Station experience muscle atrophy from disuse of their legs.
the verdict
SUPPORTED
the evidence backs this
confidence 88/100
Astronauts face muscle atrophy due to the lack of gravitational load during spaceflight, a well-documented physiological challenge on the International Space Station.
Evidence for · 3
Towards human exploration of space: the THESEUS review series on muscle and bone research priorities
2017 · cited by 129
Paper 0 establishes that microgravity during spaceflight results in muscle and bone atrophy, which countermeasures on the ISS aim to mitigate.
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More for · 2
Explainable machine learning identifies multi-omics signatures of muscle response to spaceflight in mice
2023 · cited by 19
Paper 3 analyzes muscle tissue from mice on the ISS and identifies molecular mechanisms of spaceflight-induced muscle atrophy.
Microgravity-induced skeletal muscle atrophy in women and men:Implications for long-duration spaceflights to the Moon and Mars.
2023 · cited by 12
Paper 5 demonstrates via bed-rest analogs that microgravity leads to significant muscle volume loss in human lower limbs.