Multiple longitudinal neuroimaging studies indicate that antipsychotic medication use is associated with measurable structural brain changes, including regional volume increases in the basal ganglia and progressive, dose-dependent cortical and subcortical alterations.
The retrieved papers include multiple longitudinal neuroimaging investigations demonstrating structural brain changes associated with antipsychotic medication exposure. Specifically, papers [2], [3], and [8] all report measurable anatomical alterations—such as striatal volume changes, ventricular enlargement, and cortical thickness reductions—linked to antipsychotic treatment. No papers provided refute the claim.