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the claim

Alternate-day iron supplementation improves absorption compared to daily dosing.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that alternate-day iron supplementation improves absorption compared to daily dosing?

Yes. Evidence from clinical studies demonstrates that alternate-day iron supplementation increases iron absorption and improves fractional uptake compared to consecutive daily dosing, largely by avoiding sustained hepcidin elevations.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

The analysis

The retrieved literature contains specific studies and reviews (such as papers [0] and [8]) investigating iron supplementation regimens, confirming that alternate-day dosing improves fractional absorption and reduces hepcidin concentrations relative to daily dosing. No papers refute this physiological mechanism.

Evidence for · 2
Alternate day versus consecutive day oral iron supplementation in iron-depleted women: a randomized double-blind placebo-controlled study
2023
Demonstrates that alternate-day iron supplementation improves fractional iron absorption and reduces hepcidin levels compared to daily schedules.
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Siebenthal, H. K. v., Gessler, S., Vallelian, F., Steinwendner, J., Kuenzi, U., Moretti, D., Zimmermann, M., & Stoffel, N. U. (2023). Alternate day versus consecutive day oral iron supplementation in iron-depleted women: a randomized double-blind placebo-controlled study. doi.org. https://doi.org/10.1016/j.eclinm.2023.102286

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More for · 1
Novel approaches to oral iron treatment
2019
Notes that alternate-day, low-dose schedules provide higher fractional absorption compared to daily schedules due to reduced hepcidin spikes.
Get citation
Moretti, D. (2019). Novel approaches to oral iron treatment. doi.org. https://doi.org/10.1097/HS9.0000000000000235

Receipt History
first checked05 Aug 2026
judged → SUPPORTED · 7305 Aug 2026
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