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the claim

A DNA sequence motif is defined by a statistically significant recurrence of a specific nucleotide pattern

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that a DNA sequence motif is defined by a statistically significant recurrence of a specific nucleotide pattern?

Yes. DNA sequence motifs are reliably defined in bioinformatics as recurrent nucleotide patterns identified through statistical significance testing.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the definition of a DNA sequence motif as a recurrent nucleotide pattern identified through statistical significance. Papers [0], [1], [3], and [7] all explicitly describe motif discovery and identification in terms of recurrent sequence patterns and statistical significance tests. There are no refuting papers.

Evidence for · 4
Basic local alignment search tool.
1990
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Altschul, S., Gish, W., Miller, W., Myers, E., & Lipman, D. (1990). Basic local alignment search tool.. doi.org. https://doi.org/10.1016/S0022-2836(05)80360-2

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More for · 3
Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods.
2002
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GuhaThakurta, D., Palomar, L., Stormo, G., Tedesco, P., Johnson, T., Walker, D. W., Lithgow, G., Kim, S. K., & Link, C. (2002). Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods.. doi.org. https://doi.org/10.1101/GR.228902

Identification of upstream transcription factor binding sites in orthologous genes using mixed Student’s t-test statistics
2021
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Huang, T., Xiao, H., Tian, Q., He, Z., Yuan, C., Lin, Z., Gao, X., & Yao, M. (2021). Identification of upstream transcription factor binding sites in orthologous genes using mixed Student’s t-test statistics. doi.org. https://doi.org/10.1371/journal.pcbi.1009773

ShapeME: A Tool and Web Front-end for De Novo Discovery of Structural Motifs Underpinning Protein-DNA Interactions.
2026
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JW, S., V, R., MB, W., & L, F. (2026). ShapeME: A Tool and Web Front-end for De Novo Discovery of Structural Motifs Underpinning Protein-DNA Interactions.. doi.org. https://doi.org/10.1016/j.jmb.2026.169810

Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 10004 Aug 2026
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