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the claim

Melanoma thickness and ulceration are the primary prognostic indicators of survival in early stage disease.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that melanoma thickness and ulceration are the primary prognostic indicators of survival in early stage disease?

Yes. Melanoma thickness (Breslow depth) and ulceration are consistently validated as the primary prognostic indicators of survival and recurrence in early-stage cutaneous melanoma.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The analysis

The retrieved literature extensively supports the claim that Breslow thickness and ulceration are central prognostic indicators for early-stage melanoma survival and recurrence, serving as the foundational clinical benchmark against which other biomarkers or gene expression profiles are compared.

Evidence for · 5
Clinical and Histopathological Prognostic Factors for Disease-Free Survival in Early-Stage Acral and Non-Acral Cutaneous Melanoma: A Retrospective Asian Cohort Analysis
2026
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Chiu, Y., Cheng, C., Chen, K., Li, C., Wang, T., & Tsai, C. (2026). Clinical and Histopathological Prognostic Factors for Disease-Free Survival in Early-Stage Acral and Non-Acral Cutaneous Melanoma: A Retrospective Asian Cohort Analysis. doi.org. https://doi.org/10.2147/CMAR.S577632

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More for · 4
Effect of Anatomical Site on Prognosis and Progression Pattern in Early-Stage Acral Melanoma: A Retrospective Cohort Study of 281 Cases.
2025
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Choi, M., Jung, J., Won, C., Chang, S. E., Lee, M., & Lee, W. (2025). Effect of Anatomical Site on Prognosis and Progression Pattern in Early-Stage Acral Melanoma: A Retrospective Cohort Study of 281 Cases.. doi.org. https://doi.org/10.1016/j.jaad.2025.10.065

Poor prognosis of early-stage acral melanoma with a history of trauma: a multicenter analysis of 468 patients
2025
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Teng, Y., Wu, J., Cai, X., Zhang, W., Jiang, K., Zhou, H., Guo, Z., Liu, J., Wang, Y., Liu, F., Lan, S., Meng, H., Ji, X., Xiang, M., Li, Y., & Wu, D. (2025). Poor prognosis of early-stage acral melanoma with a history of trauma: a multicenter analysis of 468 patients. doi.org. https://doi.org/10.1093/oncolo/oyaf086

Recurrence Patterns and Prognostic Factors in Sentinel Lymph Node-Negative Melanoma in a Taiwanese Cohort With Predominant Acral Melanoma.
2026
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CY, C., CY, L., TH, W., CH, T., JS, Y., & YJ, C. (2026). Recurrence Patterns and Prognostic Factors in Sentinel Lymph Node-Negative Melanoma in a Taiwanese Cohort With Predominant Acral Melanoma.. doi.org. https://doi.org/10.1111/1346-8138.70358

Evaluation of gene expression profiling beyond Breslow thickness and ulceration for prediction of distant metastases in early-stage melanoma: the population-based Dutch Early-Stage Melanoma (D-ESMEL) study
2025
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Zhou, C., Chen, Y., Mooyaart, A., Valent, E., Pozza, L., Huigh, D., Nijsten, T., & Hollestein, L. (2025). Evaluation of gene expression profiling beyond Breslow thickness and ulceration for prediction of distant metastases in early-stage melanoma: the population-based Dutch Early-Stage Melanoma (D-ESMEL) study. doi.org. https://doi.org/10.1101/2025.11.10.25339906

What does the evidence say?

The retrieved literature extensively supports the claim that Breslow thickness and ulceration are central prognostic indicators for early-stage melanoma survival and recurrence, serving as the foundational clinical benchmark against which other biomarkers or gene expression profiles are compared.

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