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the claim

A tartrate resistant acid phosphatase (TRAP) stain can confirm the diagnosis of hairy cell leukemia.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that a tartrate resistant acid phosphatase (TRAP) stain can confirm the diagnosis of hairy cell leukemia?

Yes. Tartrate-resistant acid phosphatase (TRAP) staining and immunohistochemistry are well-established diagnostic tools used to confirm hairy cell leukemia.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the premise that tartrate-resistant acid phosphatase (TRAP) serves as a classic and reliable diagnostic marker for hairy cell leukemia, both through traditional cytochemical staining and modern immunohistochemistry.

Evidence for · 3
Hairy cell identification by immunohistochemistry of tartrate-resistant acid phosphatase
1995
Demonstrates that tartrate-resistant acid phosphatase (TRAcP) has long served as an indispensable marker for hairy cell leukemia and can be identified via monoclonal antibodies.
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Janckila, A., Cardwell, E., Yam, L., & Li, C. (1995). Hairy cell identification by immunohistochemistry of tartrate-resistant acid phosphatase. doi.org. https://doi.org/10.1182/blood.v85.10.2839.bloodjournal85102839

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More for · 2
The value of tartrate resistant acid phosphatase (TRAP) immunoreactivity in diagnosis of hairy cell leukemia
2005
Shows that anti-TRAP antibody immunoreactivity provides high specificity and sensitivity in diagnosing hairy cell leukemia in bone marrow biopsies.
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AKKAYA, H., DOGAN, O., AGAN, M., & DINCOL, G. (2005). The value of tartrate resistant acid phosphatase (TRAP) immunoreactivity in diagnosis of hairy cell leukemia. doi.org. https://doi.org/10.1111/j.1600-0463.2005.apm1130302.x

Diagnosis of hairy-cell leukaemia by tartrate-resistant acid phosphatase activity in paraffin-embedded tissue sections.
1980
Indicates that tartrate-resistant acid phosphatase activity demonstrated in tissue sections aids in the differential diagnosis of hairy-cell leukaemia.
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Grouls, V. (1980). Diagnosis of hairy-cell leukaemia by tartrate-resistant acid phosphatase activity in paraffin-embedded tissue sections.. doi.org. https://doi.org/10.1136/jcp.33.6.552

What does the evidence say?

The retrieved literature consistently supports the premise that tartrate-resistant acid phosphatase (TRAP) serves as a classic and reliable diagnostic marker for hairy cell leukemia, both through traditional cytochemical staining and modern immunohistochemistry.

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