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the claim

Abnormal expression of tight junction scaffold proteins results in loss of tight junction integrity and increased blood-brain barrier permeability.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
7 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that abnormal expression of tight junction scaffold proteins results in loss of tight junction integrity and increased blood-brain barrier permeability?

Yes. Abnormal expression or degradation of tight junction scaffold proteins disrupts barrier integrity, leading to increased blood-brain barrier permeability.

Verdict: SUPPORTED · 7 sources for, 0 against · Last checked

The analysis

The retrieved papers consistently show that tight junction proteins (such as claudin-5, occludin, and ZO-1) are crucial for maintaining blood-brain barrier integrity. Abnormal expression, downregulation, or structural disruption of these proteins directly results in barrier breakdown and increased permeability across various pathological contexts.

Evidence for · 7
Specific role of the tight junction proteins occludin and claudin-5 on the blood–brain barrier during Listeria monocytogenes infection
2020
The study demonstrates that decreased expression of tight junction proteins occludin and claudin-5 correlates with destroyed tight junction integrity and enhanced blood-brain barrier permeability.
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REN, J., YANG, M., WANG, P., JIANG, J., & YAN, G. (2020). Specific role of the tight junction proteins  occludin and claudin-5 on the blood–brain barrier  during Listeria monocytogenes infection. doi.org. https://doi.org/10.21521/mw.6416

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More for · 6
Convergent blood-brain barrier breakdown in schizophrenia and autism spectrum disorders: a systematic review of preclinical animal models.
2026
The systematic review notes that preclinical models of neurodevelopmental disorders consistently exhibit disrupted tight junction protein expression alongside increased blood-brain barrier permeability.
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C, M., M, F., A, G., S, G., A, M., M, C., H, S., DS, G., MA, D., B, C., C, M., & MS, R. (2026). Convergent blood-brain barrier breakdown in schizophrenia and autism spectrum disorders: a systematic review of preclinical animal models.. doi.org. https://doi.org/10.1186/s12987-026-00818-1

Brain calcification-associated JAM2 pathogenic mutations impair JAM2-JAM3 tight junction structure and the blood-brain barrier integrity.
2026
Research on primary brain calcification shows that pathogenic mutations impair tight junction structure, specifically disrupting tight junction complexes and leading to blood-brain barrier integrity loss and leakage.
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D, Y., L, W., C, Y., Y, S., Y, G., H, W., X, C., Y, W., X, W., F, Z., X, Z., Y, C., H, W., Z, L., J, L., H, X., J, C., F, F., B, W., S, W., P, W., F, X., Z, C., Z, W., & W, L. (2026). Brain calcification-associated JAM2 pathogenic mutations impair JAM2-JAM3 tight junction structure and the blood-brain barrier integrity.. doi.org. https://doi.org/10.1111/bpa.70139

Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease.
2026
The review details how defective cell adhesion and tight junction signaling networks directly result in blood-brain barrier pathologies and breakdown.
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JH, M. (2026). Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease.. doi.org. https://doi.org/10.1161/atvbaha.126.324590

Vascular Endothelial Barrier in Salivary Glands: From Physiological Regulation to Pathological Impairment of Secretion.
2026
An analysis of salivary gland endothelial barriers highlights that aberrant tight junction expression and junctional disassembly trigger vascular leakage.
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SN, M., LL, W., GY, Y., & X, C. (2026). Vascular Endothelial Barrier in Salivary Glands: From Physiological Regulation to Pathological Impairment of Secretion.. doi.org. https://doi.org/10.3390/ijms27136076

Role of the Blood-Brain Barrier in the Pathophysiology of Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A Comparative Review.
2026
Evidence in neuropsychiatric disorders links downregulation and degradation of claudin-5 and other tight junction proteins with increased blood-brain barrier permeability.
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IS, R., O, D., AN, A., & G, A. (2026). Role of the Blood-Brain Barrier in the Pathophysiology of Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A Comparative Review.. doi.org. https://doi.org/10.3390/ph19091483

Intestinal and Blood-Brain Barrier Dysfunction in Lupus: Emerging Mechanisms and Modulation by Cinnamon.
2026
Studies on systemic lupus erythematosus indicate that alteration and disruption of tight junction protein distribution strongly correlate with increased biological barrier permeability.
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G, M., GA, A. T., G, A. A., & N, F. (2026). Intestinal and Blood-Brain Barrier Dysfunction in Lupus: Emerging Mechanisms and Modulation by Cinnamon.. doi.org. https://doi.org/10.3390/molecules31142514

What does the evidence say?

The retrieved papers consistently show that tight junction proteins (such as claudin-5, occludin, and ZO-1) are crucial for maintaining blood-brain barrier integrity. Abnormal expression, downregulation, or structural disruption of these proteins directly results in barrier breakdown and increased permeability across various pathological contexts.

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