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The pathogenesis of fever in humans begins with the production of endogenous pyrogen by phagocytic leukocytes in response to exogenous pyrogens.

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SUPPORTED
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2 sources for · 0 against

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Is it true that the pathogenesis of fever in humans begins with the production of endogenous pyrogen by phagocytic leukocytes in response to exogenous pyrogens?

Yes. The pathogenesis of fever involves the release of endogenous pyrogens by phagocytic leukocytes in response to microbial or exogenous pyrogen triggers.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

Evidence for · 2
2004
This review outlines the classic concept that bacterial products (exogenous pyrogens) induce the host-derived production of endogenous pyrogen (pyrogenic cytokines), which acts to produce fever.
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Dinarello, C. A. (2004). Review: Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. doi.org. https://doi.org/10.1177/09680519040100040301

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More for · 1
1974
This study examines the mechanisms by which endogenous pyrogen (EP) is released by human blood leukocytes in vitro, supporting its role as the mediator of fever.
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Bodel, P. (1974). Studies on the Mechanism of Endogenous Pyrogen Production II. Role of Cell Products in the Regulation of Pyrogen Release from Blood Leukocytes. doi.org. https://doi.org/10.1128/iai.10.3.451-457.1974

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