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the claim

Autoimmune diseases are more prevalent in women than in men.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
6 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that autoimmune diseases are more prevalent in women than in men?

Yes. Extensive clinical, epidemiological, and immunological studies consistently demonstrate that autoimmune diseases are significantly more prevalent in women than in men.

Verdict: SUPPORTED · 6 sources for, 0 against · Last checked

The analysis

The retrieved papers consistently support the claim that autoimmune diseases are more prevalent in women, citing immunological, hormonal, and genetic mechanisms.

Evidence for · 6
2022
Reviews evidence showing that women exhibit increased susceptibility to autoimmune diseases due to immune system dimorphism.
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Dodd, K. C. & Menon, M. (2022). Sex bias in lymphocytes: Implications for autoimmune diseases. doi.org. https://doi.org/10.3389/fimmu.2022.945762

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More for · 5
2020
Discusses how general autoimmune diseases are more prevalent in females than males, noting genetic and hormonal predisposing factors.
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Mousavi, M. J., Mahmoudi, M., & Ghotloo, S. (2020). Escape from X chromosome inactivation and female bias of autoimmune diseases. doi.org. https://doi.org/10.1186/s10020-020-00256-1

2026
Identifies a sex-specific bias in thymic T cell selection toward autoimmunity in females, explaining higher disease susceptibility.
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H, V., V, Q., L, A., C, J., V, M., C, A., P, B., N, C., V, D., J, D., G, F., K, L. G., OF, N. T., M, P., P, S., A, S., E, M., & D, K. (2026). Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females.. doi.org. https://doi.org/10.7554/elife.109041

2026
Highlights the markedly higher prevalence of autoimmune diseases in women across most conditions.
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Calabrò, A., Accardi, G., Aiello, A., Zarcone, R., & Candore, G. (2026). Autoimmune diseases are more common in women: insights into sex and gender differences in autoimmunity. doi.org. https://doi.org/10.37349/ei.2026.1003241

2026
Confirms in a community sample that antinuclear antibody positivity, a marker for autoimmunity, is significantly higher in women.
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T, T., Y, K., T, I., & T, H. (2026). Prevalence and correlates of antinuclear antibodies in a Japanese community sample: a cross-sectional study.. doi.org. https://doi.org/10.1016/j.curtheres.2026.100845

2026
Finds that women have markedly higher rates of thyroid autoantibody positivity compared to men.
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Y, W., Y, X., H, W., Y, X., & Z, H. (2026). Retrospective analysis of thyroid functions and sonographic characteristics of the thyroid gland in a health check-up population in China during 2020-2024.. doi.org. https://doi.org/10.3389/fpubh.2026.1838770

What does the evidence say?

The retrieved papers consistently support the claim that autoimmune diseases are more prevalent in women, citing immunological, hormonal, and genetic mechanisms.

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