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the claim

Candida albicans can contribute to the development of dental caries by enhancing the cariogenicity of Streptococcus mutans.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Candida albicans can contribute to the development of dental caries by enhancing the cariogenicity of Streptococcus mutans?

Yes. Multiple recent studies confirm that Candida albicans and Streptococcus mutans engage in cross-kingdom interactions, such as quorum sensing and co-aggregation via specialized surface proteins, which synergistically enhance biofilm formation and the development of dental caries.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the claim that Candida albicans contributes to dental caries by synergistically interacting with Streptococcus mutans. Multiple recent studies (Papers 1, 5, 6, and 8) detail the precise mechanisms—including extracellular membrane vesicles, quorum sensing, ubiquitination modulation, and adhesin-mediated co-aggregation—by which these two organisms enhance biofilm formation, acid production, and overall cariogenicity.

Evidence for · 4
Streptococcus mutans regulates ubiquitin modification of Candida albicans in the bacterial-fungal interaction.
2025
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Y, Z., Z, G., Z, L., Q, W., X, X., & X, P. (2025). Streptococcus mutans regulates ubiquitin modification of Candida albicans in the bacterial-fungal interaction.. doi.org. https://doi.org/10.1371/journal.ppat.1012887

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More for · 3
Review: Quorum sensing mechanism between Streptococcus mutans and Candida albicans in the pathogenesis of dental caries
2023
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Kriswandini, I. L. & Almas, R. (2023). Review: Quorum sensing mechanism between Streptococcus mutans and Candida albicans in the pathogenesis of dental caries. doi.org. https://doi.org/10.30574/wjarr.2023.17.1.0066

Artemisinins inhibited the synergistic cariogenic effect between <i>Candida albicans</i> and <i>Streptococcus mutans</i>.
2026
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J, Z., Z, Z., J, S., Y, L., L, L., L, G., Z, M., Y, Z., B, L., L, C., X, Z., & B, R. (2026). Artemisinins inhibited the synergistic cariogenic effect between <i>Candida albicans</i> and <i>Streptococcus mutans</i>.. doi.org. https://doi.org/10.3389/fcimb.2026.1950360

The <i>Streptococcus mutans</i> collagen-binding protein Cnm enhances early biofilm formation with <i>Candida albicans</i>.
2026
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C, K., L, B., L, P., J, F., & J, A. (2026). The <i>Streptococcus mutans</i> collagen-binding protein Cnm enhances early biofilm formation with <i>Candida albicans</i>.. doi.org. https://doi.org/10.1128/aem.01046-26

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