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the claim

The overuse of antibiotics can lead to the spread of antimicrobial resistance.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
10 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that the overuse of antibiotics can lead to the spread of antimicrobial resistance?

Yes. Extensive scientific literature consistently demonstrates that the overuse and misuse of antibiotics create strong selective pressures that accelerate the emergence and global spread of antimicrobial resistance.

Verdict: SUPPORTED · 10 sources for, 0 against · Last checked

The analysis

The retrieved literature thoroughly supports the claim that antibiotic overuse leads to antimicrobial resistance, highlighting evidence from clinical, agricultural, and environmental One Health perspectives.

Evidence for · 10
2022
Discusses how antibiotic exposure and clinical usage drive selection pressures and evolutionary changes in plasmid-mediated resistance.
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Benz, F. & Hall, A. R. (2022). Host-specific plasmid evolution explains the variable spread of clinical antibiotic-resistance plasmids. doi.org. https://doi.org/10.1101/2022.07.06.498992

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More for · 9
2026
Notes that the overuse and improper use of antibiotics create selective pressure that promotes the emergence and spread of resistant strains.
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AV, G., K, A., M, T., SQ, S., & R, P. (2026). An insight on the progress of quorum sensing mechanisms, impact of quorum sensing on antimicrobial resistance and quorum sensing inhibition: A narrative review.. doi.org. https://doi.org/10.1016/j.enzmictec.2026.110973

2026
Highlights how antibiotic overuse and misuse in intensive livestock farming drives the enrichment and dissemination of antimicrobial resistance genes along the food chain.
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Y, L., ZX, P., & YN, W. (2026). [Molecular mechanisms and control strategies for the potential transmission of bacterial antibiotic resistance along the food production chain].. doi.org. https://doi.org/10.3760/cma.j.cn112150-20250917-00902

2026
Identifies the overuse of antibiotics in healthcare and agriculture as a principal driver of global antimicrobial resistance.
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N, M., RO, O., M, M. A., & 3rd, L. D. (2026). Antimicrobial resistance within the one health lens: global drivers, mechanisms and public health policy gaps in low resource settings.. doi.org. https://doi.org/10.3389/fcimb.2026.1862774

2026
Reports that One Health drivers include widespread antibiotic overuse across human healthcare and agriculture, accelerating resistance.
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S, P., S, S., M, B., S, Y., P, H., & NK, R. (2026). Antibiotic Resistance and the Return to a Pre-Antibiotic Era: A Critical Narrative Review of a Global Catastrophe.. doi.org. https://doi.org/10.3390/biomedicines14092053

2026
Notes that the growing challenge of antimicrobial resistance is directly driven by the misuse and overuse of antibiotics.
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T, P., H, S., J, P., & P, B. (2026). Antibiotic Potency and Resistance: A Critical Review of Analytical and Microbiological Methodologies.. doi.org. https://doi.org/10.1002/bmc.70523

2026
States that antimicrobial resistance is heavily driven by inappropriate antimicrobial use across human healthcare, livestock, and agriculture.
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N, A. (2026). Antimicrobial Resistance at the Human-Animal-Environment Interface: A One Health Perspective on Drivers, Transmission, and Public Health Responses.. doi.org. https://doi.org/10.1002/hsr2.72964

2026
Points out that widespread inappropriate antibiotic use and unregulated access have accelerated the development and spread of resistance in fragile health systems.
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WM, H. (2026). Antimicrobial Resistance in Somalia: A Growing Public Health Crisis in a Fragile Health System-A Narrative Review of Challenges, Healthcare Gaps, and Policy Recommendations.. doi.org. https://doi.org/10.2147/idr.s624197

2026
Identifies antibiotic misuse as a major external driver of the emergence and spread of drug resistance.
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Y, O., Y, Z., Z, L., X, W., N, L., X, L., J, L., Y, N., J, C., J, T., C, X., P, L., Y, Z., & W, G. (2026). Drug resistance of <i>Mycoplasma genitalium</i>: mechanism and regional distribution.. doi.org. https://doi.org/10.3389/fcimb.2026.1789671

2026
Identifies antibiotic prescribing and use across human and animal health as key drivers within a systems-thinking approach to antimicrobial resistance.
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Y, P., S, J., & TM, W. (2026). Antimicrobial resistance in the Northern Territory, Australia: insights from a systems thinking approach to human health.. doi.org. https://doi.org/10.1186/s42522-026-00222-7

What does the evidence say?

The retrieved literature thoroughly supports the claim that antibiotic overuse leads to antimicrobial resistance, highlighting evidence from clinical, agricultural, and environmental One Health perspectives.

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