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Insulin resistance causes polycystic ovary syndrome in women.
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CONTESTED PARTIAL
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2 sources for · 2 against
Is it true that insulin resistance causes polycystic ovary syndrome in women?
Partly. Evidence is mixed and only partial: one review calls insulin resistance and hyperinsulinemia key features in PCOS pathogenesis, and a Bahraini case-control study found hyperinsulinemia independently associated with PCOS, while a molecular review states that defective insulin activity in PCOS causes insulin resistance, reversing the proposed direction. No retrieved source settles whether insulin resistance causes PCOS.
Verdict: CONTESTED PARTIAL · 2 sources for, 2 against · Last checked
Evidence for · 2
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Vitamin D and its clinical effects in women with polycystic ovary syndrome. (2026). doi.org. https://doi.org/10.63909/1453043
Evidence against · 2
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Insulin resistance. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Insulin_resistance
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More for · 1
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MA, A., J, G., K, G., & NM, D. (2012). Sensitive and specific markers for insulin resistance, hyperandrogenemia, and inappropriate gonadotrophin secretion in women with polycystic ovary syndrome: a case-control study from Bahrain. dovepress.com. http://www.dovepress.com/sensitive-and-specific-markers-for-insulin-resistance-hyperandrogenemi-a9892
More against · 1
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Molecular mechanisms of insulin resistance in polycystic ovary syndrome. (2006). doi.org. https://doi.org/10.1016/j.molmed.2006.05.006
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