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the claim
Typically 60–80% of CpGs in the human genome are methylated.
the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against
Is it true that typically 60–80% of CpGs in the human genome are methylated?
Yes. Multiple peer-reviewed scientific sources estimate that approximately 70% to 80% (or up to 90%) of CpG sites across the mammalian and human genome are methylated.
Verdict: SUPPORTED · 2 sources for, 0 against · Last checked
The analysis
Judged against statistical and reference sources.
Evidence for · 2
Explicitly estimates that 70-80% of CpG sites in the mammalian genome are methylated.
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Semantic Scholar peS2o: LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond. (n.d.). Semantic Scholar peS2o. https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-022-02319-z
2 recorded entries grouped as this source
Repeats the estimate that 70-80% of CpG sites in mammalian genomes are methylated.
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Semantic Scholar peS2o: LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond. (n.d.). Semantic Scholar peS2o. https://doi.org/10.1186/s13046-022-02319-z
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More for · 1
Notes that 70-90% of all CpGs in the human genome are in regions typically methylated under normal conditions.
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PLOS (all journals): The Prognostic Value of Global DNA Hypomethylation in Cancer: A Meta-Analysis. (n.d.). PLOS (all journals). https://doi.org/10.1371/journal.pone.0106290
What does the evidence say?
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