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the claim
Topical retinol increases the rate of skin cell turnover in the epidermis.
the verdict
SUPPORTED
the evidence backs this
Recorded sources
8 sources for · 0 against
Is it true that topical retinol increases the rate of skin cell turnover in the epidermis?
Yes. A Cleveland Clinic page states directly that topical retinol increases skin cell turnover, and several peer-reviewed studies report retinol stimulating keratinocyte proliferation and increasing epidermal thickness in human skin, which supports the claim though most measure proliferation or thickness rather than turnover rate itself.
Verdict: SUPPORTED · 8 sources for, 0 against · Last checked
Evidence for · 8
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Mambwe, B., Mellody, K. T., Kiss, O., O'Connor, C., Bell, M., Watson, R. E. B., & Langton, A. K. (2025). Cosmetic retinoid use in photoaged skin: A review of the compounds, their use and mechanisms of action.. doi.org. https://doi.org/10.1111/ics.13013
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More for · 7
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The Role of Retinoids in Acne Treatment and Anti-Ageing: A Critical Narrative Review of Mechanisms, Clinical Evidence, and Therapeutic Translation. (2026). hal.science. https://hal.science/hal-05684718v1
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Retinol: Cream, Serum, What It Is, Benefits, How To Use. (n.d.). my.clevelandclinic.org. https://my.clevelandclinic.org/health/treatments/23293-retinol
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A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin. (n.d.). cir.nii.ac.jp. https://doi.org/10.1111/jocd.12193
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UVA and UVB Decrease the Expression of CD44 and Hyaluronate in Mouse Epidermis, which is Counteracted by Topical Retinoids. (n.d.). cir.nii.ac.jp. https://doi.org/10.1562/2006-02-10-ra-801
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Effect of Retinoic Acid on HaCaT and NIH-3T3 cells in an in vitro 3D Collagen Cell Culture Skin Model. (2023). doi.org. https://doi.org/10.33697/ajur.023.093
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Molecular basis of retinol anti‐ageing properties in naturally aged human skin in vivo. (n.d.). cir.nii.ac.jp. https://doi.org/10.1111/ics.12348
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Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.5114/ada.2019.87443
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