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the claim

Topical retinol increases the rate of skin cell turnover in the epidermis.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
8 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that topical retinol increases the rate of skin cell turnover in the epidermis?

Yes. A Cleveland Clinic page states directly that topical retinol increases skin cell turnover, and several peer-reviewed studies report retinol stimulating keratinocyte proliferation and increasing epidermal thickness in human skin, which supports the claim though most measure proliferation or thickness rather than turnover rate itself.

Verdict: SUPPORTED · 8 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 8
2025
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Mambwe, B., Mellody, K. T., Kiss, O., O'Connor, C., Bell, M., Watson, R. E. B., & Langton, A. K. (2025). Cosmetic retinoid use in photoaged skin: A review of the compounds, their use and mechanisms of action.. doi.org. https://doi.org/10.1111/ics.13013

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More for · 7
2026
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The Role of Retinoids in Acne Treatment and Anti-Ageing: A Critical Narrative Review of Mechanisms, Clinical Evidence, and Therapeutic Translation. (2026). hal.science. https://hal.science/hal-05684718v1

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Retinol: Cream, Serum, What It Is, Benefits, How To Use. (n.d.). my.clevelandclinic.org. https://my.clevelandclinic.org/health/treatments/23293-retinol

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A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin. (n.d.). cir.nii.ac.jp. https://doi.org/10.1111/jocd.12193

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UVA and UVB Decrease the Expression of CD44 and Hyaluronate in Mouse Epidermis, which is Counteracted by Topical Retinoids. (n.d.). cir.nii.ac.jp. https://doi.org/10.1562/2006-02-10-ra-801

2023
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Effect of Retinoic Acid on HaCaT and NIH-3T3 cells in an in vitro 3D Collagen Cell Culture Skin Model. (2023). doi.org. https://doi.org/10.33697/ajur.023.093

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Molecular basis of retinol anti‐ageing properties in naturally aged human skin in vivo. (n.d.). cir.nii.ac.jp. https://doi.org/10.1111/ics.12348

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Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.5114/ada.2019.87443

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