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Gut microbiome composition is associated with Alzheimer's disease.
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SUPPORTED
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9 sources for · 0 against
Is it true that gut microbiome composition is associated with Alzheimer's disease?
Yes. Peer-reviewed studies report that gut microbiome composition differs between people with Alzheimer's disease and cognitively unimpaired individuals, with the difference replicated in an independent cohort and correlated with CSF biomarkers of AD pathology. Additional reviews and a registered study describe the microbiome as linked to AD, though several of these are narrative or protocol-level rather than primary findings.
Verdict: SUPPORTED · 9 sources for, 0 against · Last checked
Evidence for · 9
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Haller, D. (2026). The Gut Microbiome in Health and Disease. play.google.com. https://play.google.com/store/books/details?id=d00LEgAAQBAJ&source=gbs_api
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More for · 8
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Gut microbiome compositional and functional features associate with Alzheimer's disease pathology. (2025). doi.org. https://doi.org/10.1002/alz.70417
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Kang, J. W., Khatib, L., Heston, M., Dilmore, A., Labus, J. S., Deming, Y., Schimmel, L., Blach, C., McDonald, D., González, A., Bryant, M. M., Sanders, K., Schwartz, A., Ulland, T., Johnson, S. C., Asthana, S., Carlsson, C., Chin, N. A., Blennow, K., & Zetterberg, H. (2024). Gut Microbiome Compositional and Functional Features Associate with Alzheimer’s Disease Pathology. doi.org. https://doi.org/10.1101/2024.09.04.24313004
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Impacts of host genetics on gut microbiome composition in Alzheimer’s disease. (2026). doi.org. https://doi.org/10.1186/s40168-026-02342-8
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Pasinetti, G. M. (2022). Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease. play.google.com. https://play.google.com/store/books/details?id=wQN6EAAAQBAJ&source=gbs_api
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Nutrition, Gut Microbiota, and Alzheimer's Disease. (n.d.). cir.nii.ac.jp. https://doi.org/10.3389/fpsyt.2021.712673
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Taxonomic and Functional Composition of the Intestinal Microbiome: a Predictor of Rapid Cognitive Decline in Patients With Alzheimer's Disease. (2017). clinicaltrials.gov. https://clinicaltrials.gov/study/NCT03487380
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Perturbations associated with hungry gut microbiome and postbiotic perspectives to strengthen the microbiome health. (2021). doi.org. https://doi.org/10.1016/j.fufo.2021.100043
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Fongang, B., Satizabal, C., Kautz, T. F., Wadop, Y. N., Muhammad, J. A. S., Vasquez, E. L., Mathews, J. J., Gireud-Goss, M., Saklad, A., Himali, J., Beiser, A., Cavazos, J., Mahaney, M., Maestre, G., Decarli, C., Shipp, E. L., Vasan, R., & Seshadri, S. (2022). Cerebral small vessel disease burden is associated with decreased abundance of gut Barnesiella intestinihominis bacterium in the Framingham Heart Study. doi.org. https://doi.org/10.1038/s41598-023-40872-5
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