George C. Williams proposed the antagonistic pleiotropy hypothesis in 1957.

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SUPPORTED

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4 sources for · 0 against

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Is it true that George C. Williams proposed the antagonistic pleiotropy hypothesis in 1957?

Yes. Multiple reliable sources confirm that George C. Williams further developed and proposed the antagonistic pleiotropy hypothesis in a 1957 paper.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked 4 Oct 2026

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Evidence for · 4

Wikipedia: Antagonistic pleiotropy hypothesis

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Wikipedia: Antagonistic pleiotropy hypothesis. (n.d.). Wikipedia. https://en.wikipedia.org/wiki/Antagonistic_pleiotropy_hypothesis

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Wikipedia: Wikipedia: Antagonistic pleiotropy hypothesis

States the hypothesis was developed further by George C. Williams in 1957.

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Wikipedia: Wikipedia: Antagonistic pleiotropy hypothesis. (n.d.). Wikipedia. https://en.wikipedia.org/wiki/Antagonistic_pleiotropy_hypothesis

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More for · 3

Wikipedia: Pleiotropy

Reference article covering this claim directly

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Wikipedia: Pleiotropy. (n.d.). Wikipedia. https://en.wikipedia.org/wiki/Pleiotropy

LibreTexts: LibreTexts: 3: The Evolution of Aging

Explicitly attributes the antagonistic pleiotropy hypothesis of aging to George C. Williams.

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LibreTexts: LibreTexts: 3%3A The Evolution of Aging. (n.d.). LibreTexts. https://bio.libretexts.org/Courses/CT_State_Northwestern/General_Ecology_Ecology/Chapter_8%3A_Life_Histories/3%3A_The_Evolution_of_Aging

Semantic Scholar peS2o: Is antagonistic pleiotropy ubiquitous in aging biology?

Confirms George Williams' 1957 paper developed the antagonistic pleiotropy hypothesis.

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Semantic Scholar peS2o: Is antagonistic pleiotropy ubiquitous in aging biology?. (n.d.). Semantic Scholar peS2o. https://academic.oup.com/emph/article-pdf/2018/1/287/28076922/eoy033.pdf

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