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Carbon monoxide is highly toxic to aerobic organisms because it binds to heme with greater affinity than oxygen, thereby excluding oxygen.

the verdict
SUPPORTED
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Recorded sources
2 sources for · 0 against

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Is it true that carbon monoxide is highly toxic to aerobic organisms because it binds to heme with greater affinity than oxygen, thereby excluding oxygen?

Yes. Carbon monoxide is highly toxic to aerobic organisms primarily because it binds to the heme groups of hemoglobin with a high affinity, thereby displacing and excluding oxygen transport.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

Evidence for · 2
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response
2022
Discusses how carbon monoxide binds to a large number of hemoproteins, including hemoglobin and cytochrome c oxidase, establishing its high affinity for heme targets.
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Yuan, Z., Cruz, L. K. C. D. L., Yang, X., & Wang, B. (2022). Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response. doi.org. https://doi.org/10.1124/pharmrev.121.000564

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More for · 1
When Red Blood Cells Meet Carbon Monoxide: Yin and Yang in Medicines and Pharmaceuticals.
2026
Explains that carbon monoxide is a poisonous gas because it disrupts the functional oxygen transport of red blood cells by binding the heme of hemoglobin with high affinity.
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T, N., VTG, C., M, O., & K, T. (2026). When Red Blood Cells Meet Carbon Monoxide: Yin and Yang in Medicines and Pharmaceuticals.. doi.org. https://doi.org/10.3390/ph19040634

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