Rh incompatibility between mother and fetus complicates pregnancy.

Is it true that Rh incompatibility between mother and fetus complicates pregnancy?

Yes. A clinic reference and an immunology teaching article state that Rh antigen incompatibility between mother and fetus causes hemolytic disease of the newborn, with effects ranging from mild to severe including jaundice, liver failure, heart failure and stillbirth. A case review and an antibody study add that maternal anti-Rh IgG crosses the placenta and that the D antigen is involved in most cases of hemolytic disease of the newborn.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked 3 Oct 2026

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Immunologic Effect of the Incompatibility of the Transplantation Antigen Between Mother and Fetus on the Course of Pregnancy. (n.d.). cir.nii.ac.jp. https://cir.nii.ac.jp/crid/1520290883663764864

Rhesus (Rh) Factor: Incompatibility, Complications & Pregnancy. (n.d.). my.clevelandclinic.org. https://my.clevelandclinic.org/health/diseases/21053-rh-factor

Fetal–maternal incompatibility in the Rh system. Rh isoimmunization associated with hereditary spherocytosis: case presentation and review of the literature - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.47162/RJME.63.1.26

ヒトの血液型抗体の免疫グロブリンのクラスに関する研究. (n.d.). cir.nii.ac.jp. https://doi.org/10.2974/kmj1951.32.439

Maurizio, C. (2021). Design, Implementation, and Assessment of an Interactive Simulation to Teach Undergraduate Immunology Students Hemolytic Disease of the Newborn. eric.ed.gov. https://doi.org/10.1152/advan.00008.2021