Acid reducers may interact with certain prescription drugs.

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that acid reducers may interact with certain prescription drugs?

Yes. Acid reducers, particularly certain proton pump inhibitors, can significantly interact with prescription medications such as clopidogrel by altering drug metabolism and bioavailability.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked 3 Oct 2026

The analysis

The retrieved papers provide robust clinical and pharmacokinetic evidence showing that acid reducers (PPIs) interact with prescription drugs due to CYP450 enzyme metabolism and pH-dependent absorption changes.

Evidence for · 2

Cytochrome P450 Enzymes in the Metabolism of Proton Pump Inhibitors: Implications for the Treatment of Peptic Ulcers.

2026

The study discusses how proton pump inhibitors are metabolized by cytochrome P450 enzymes and highlights drug-drug interactions, particularly with agents like clopidogrel.

Get citation

CB, S., S, Y., & S, P. (2026). Cytochrome P450 Enzymes in the Metabolism of Proton Pump Inhibitors: Implications for the Treatment of Peptic Ulcers.. doi.org. https://doi.org/10.2174/0113894501451092260904093209

See more details

More for · 1

Assessment of Pharmacokinetic Interaction and Clinical Efficacy of Clopidogrel Co-administered with Ilaprazole.

2026

The study demonstrates that specific proton pump inhibitors like pantoprazole significantly interact with and reduce the bioavailability and activation of clopidogrel.

Get citation

D, N., P, A., V, T. M., & R, N. A. (2026). Assessment of Pharmacokinetic Interaction and Clinical Efficacy of Clopidogrel Co-administered with Ilaprazole.. doi.org. https://doi.org/10.1002/cpdd.70095

What does the evidence say?

Receipt History

Anyone with this link can read the claim and its public receipt, including any personal information in that text. Open permanent receipt.

Check your own claim

Challenge the receipt

I have a source that contradicts this verdict I have a source that supports it No source: request a receipt review Requests are recorded for review. This does not start an automatic check or guarantee a response time.

See the evidence timeline

Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.

This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work