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the claim

Nitric oxide stimulates soluble guanylate cyclase activity.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
10 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that nitric oxide stimulates soluble guanylate cyclase activity?

Yes. Nitric oxide is well established as a physiological activator of soluble guanylate cyclase, driving the synthesis of cyclic GMP to regulate vascular tone and other biological processes.

Verdict: SUPPORTED · 10 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the fundamental biochemical mechanism that nitric oxide stimulates soluble guanylate cyclase activity to produce cGMP, forming the basis of the NO-sGC-cGMP signaling pathway.

Evidence for · 10
Safety, pharmacokinetic, and pharmacodynamic characteristics of SK-08, a soluble guanylate cyclase activator, after oral administration in healthy participants: a randomized phase 1 trial.
2026
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J, L., Y, D., H, Z., H, J., Y, Z., J, R., C, Y., N, X., Y, X., L, Z., Y, S., D, J., & J, Y. (2026). Safety, pharmacokinetic, and pharmacodynamic characteristics of SK-08, a soluble guanylate cyclase activator, after oral administration in healthy participants: a randomized phase 1 trial.. doi.org. https://doi.org/10.1186/s12882-026-05138-y

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More for · 9
Soluble Guanylate Cyclase Modulators in Glaucoma and Ocular Fibrosis: Mechanisms, Translational Evidence, and Therapeutic Challenges.
2026
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MSA, M. (2026). Soluble Guanylate Cyclase Modulators in Glaucoma and Ocular Fibrosis: Mechanisms, Translational Evidence, and Therapeutic Challenges.. doi.org. https://doi.org/10.1177/10807683261459859

Gasotransmitters in cancers: multiple mechanisms, crosstalk, and therapeutic implications.
2026
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M, B., CE, V., E, I., YM, S., M, A., LJ, B., & C, L. (2026). Gasotransmitters in cancers: multiple mechanisms, crosstalk, and therapeutic implications.. doi.org. https://doi.org/10.4103/mgr.medgasres-d-26-00085

Beyond the Four Pillars: A Risk-Targeted Framework for Vericiguat-A Narrative Review.
2026
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J, K., A, K., R, G., E, L., JM, U., J, R., P, N., N, M., Ł, S., & EP, N. (2026). Beyond the Four Pillars: A Risk-Targeted Framework for Vericiguat-A Narrative Review.. doi.org. https://doi.org/10.3390/jcm15145749

Advances in Cardiovascular Pharmacotherapy: VII. Soluble Guanylate Cyclase Stimulators in Pulmonary Hypertension and Heart Failure.
2026
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PS, P., D, H., JK, F., & GJ, C. (2026). Advances in Cardiovascular Pharmacotherapy: VII. Soluble Guanylate Cyclase Stimulators in Pulmonary Hypertension and Heart Failure.. doi.org. https://doi.org/10.1053/j.jvca.2026.02.035

Vericiguat in the Post-Stabilization Phase of HFrEF: Targeting Residual Risk Across the Ischemia-Decompensation Continuum.
2026
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B, K., C, P., R, V., GM, R., M, K., KJ, F., J, B., Z, K., P, S., K, K., V, N., P, M., G, G., & T, U. (2026). Vericiguat in the Post-Stabilization Phase of HFrEF: Targeting Residual Risk Across the Ischemia-Decompensation Continuum.. doi.org. https://doi.org/10.3390/ijms27125301

Vasodilatory Effects of Trans -3-Methoxy-β-Nitrostyrene, a Synthetic Nitroderivative, on Rat Thoracic Aorta: Involvement of Soluble Guanylate Cyclase Stimulation.
2026
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YAS, G., AIA, S., LR, M., GP, D., JKL, V., RS, B., PJC, M., & S, L. (2026). Vasodilatory Effects of Trans -3-Methoxy-β-Nitrostyrene, a Synthetic Nitroderivative, on Rat Thoracic Aorta: Involvement of Soluble Guanylate Cyclase Stimulation.. doi.org. https://doi.org/10.1097/fjc.0000000000001783

Therapeutic Modulation of Nitric Oxide Pathways to Address Insulin Resistance in Cardiovascular-Kidney-Metabolic Syndrome.
2026
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LM, C., VD, B., I, D., R, B., M, C., TG, A., MV, M., MG, P., CA, G., A, C., & OH, O. (2026). Therapeutic Modulation of Nitric Oxide Pathways to Address Insulin Resistance in Cardiovascular-Kidney-Metabolic Syndrome.. doi.org. https://doi.org/10.3390/ijms27177701

Vasorelaxant Effects of Wild Jujube Leaf Aqueous Extract: Endothelial NO/cGMP/SERCA Signaling, Antioxidant Activity, and AI-Based Molecular Docking.
2026
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C, A., ZLE, A., MH, Y., A, M., A, A., I, D., N, E., H, M., A, L., S, S., A, Z., & S, S. (2026). Vasorelaxant Effects of Wild Jujube Leaf Aqueous Extract: Endothelial NO/cGMP/SERCA Signaling, Antioxidant Activity, and AI-Based Molecular Docking.. doi.org. https://doi.org/10.3390/molecules31183252

Mechanisms Underlying the Biphasic Effects of Hydrogen Sulfide in Rat Intrapulmonary Arteries.
2026
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A, T., E, A., A, A., S, A., U, S., & E, S. (2026). Mechanisms Underlying the Biphasic Effects of Hydrogen Sulfide in Rat Intrapulmonary Arteries.. doi.org. https://doi.org/10.3390/biomedicines14092043

What does the evidence say?

The retrieved literature consistently supports the fundamental biochemical mechanism that nitric oxide stimulates soluble guanylate cyclase activity to produce cGMP, forming the basis of the NO-sGC-cGMP signaling pathway.

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