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the claim

Fish oil supplementation increases LDL cholesterol.

the verdict
CONTESTED PARTIAL
Recorded sources
5 sources for · 3 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that fish oil supplementation increases LDL cholesterol?

Partly. Several small trials and one meta-analysis in specific populations (hypertriglyceridemic adults, type 2 diabetics) report that fish oil supplementation raises LDL cholesterol, while other trials in healthy subjects, type 2 diabetics, and chronic kidney disease patients found no significant LDL change. The evidence covers only particular populations and does not settle the general claim.

Verdict: CONTESTED PARTIAL · 5 sources for, 3 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 5
Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults
2013
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Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. (2013). doi.org. https://doi.org/10.1016/j.numecd.2011.06.003

Evidence against · 3
Effect of Fish Oil Versus Corn Oil Supplementation on LDL and HDL Subclasses in Type 2 Diabetic Patients
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Effect of Fish Oil Versus Corn Oil Supplementation on LDL and HDL Subclasses in Type 2 Diabetic Patients. (n.d.). cir.nii.ac.jp. https://doi.org/10.2337/diacare.25.10.1704

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More for · 4
Fish oil supplementation in type 2 diabetes: a quantitative systematic review.
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Fish oil supplementation in type 2 diabetes: a quantitative systematic review.. (n.d.). cir.nii.ac.jp. https://doi.org/10.2337/diacare.23.9.1407

Heterogeneity of low density lipoprotein responses to fish-oil supplementation in hypertriglyceridemic subjects.
1989
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Heterogeneity of low density lipoprotein responses to fish-oil supplementation in hypertriglyceridemic subjects.. (1989). doi.org. https://doi.org/10.1161/01.atv.9.3.345

A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease.
2012
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A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease.. (2012). pubmed.ncbi.nlm.nih.gov. https://pubmed.ncbi.nlm.nih.gov/22113870

Gene-diet interactions with polymorphisms of the MGLL gene on plasma low-density lipoprotein cholesterol and size following an omega-3 polyunsaturated fatty acid supplementation: a clinical trial.
2014
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Catherine, O., Iwona, R., Simone, L., Benoit, L., Patrick, C., & Marie-Claude, V. (2014). Gene-diet interactions with polymorphisms of the MGLL gene on plasma low-density lipoprotein cholesterol and size following an omega-3 polyunsaturated fatty acid supplementation: a clinical trial.. archive.org. https://archive.org/details/pubmed-PMC4040477

More against · 2
Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects.
2012
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Ottestad, I., Hassani, S., Borge, G. I., Kohler, A., Vogt, G., & Hyötyläinen, T. (2012). Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects.. doi.org. https://doi.org/10.1371/journal.pone.0042550

The Effects of Fish Oil Supplementation on Lipid Levels in Non-Hemodialysis Chronic Kidney Disease Patients
2013
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The Effects of Fish Oil Supplementation on Lipid Levels in Non-Hemodialysis Chronic Kidney Disease Patients. (2013). hal.science. https://hal.science/hal-05541355v1

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