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the claim

Circulating microRNA is highly stable in blood, making it a potential biomarker for malignancies.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
6 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that circulating microRNA is highly stable in blood, making it a potential biomarker for malignancies?

Yes. Circulating microRNAs are stable in blood and protected by carriers like extracellular vesicles, supporting their use as promising non-invasive liquid biopsy biomarkers for various malignancies.

Verdict: SUPPORTED · 6 sources for, 0 against · Last checked

The analysis

Multiple studies and reviews indicate that circulating microRNAs are stable in blood (often protected inside extracellular vesicles or exosomes) and show strong potential as diagnostic and prognostic biomarkers for various cancers.

Evidence for · 6
Circulating MicroRNA Biomarker Studies: Pitfalls and Potential Solutions
2015
The review notes that circulating microRNAs are widely proposed as disease biomarkers for neoplastic disease, supported by their stability in biofluids.
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Witwer, K. W. (2015). Circulating MicroRNA Biomarker Studies: Pitfalls and Potential Solutions. doi.org. https://doi.org/10.1373/clinchem.2014.221341

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More for · 5
Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools
2020
Extracellular vesicles protect their molecular cargoes, such as miRNAs, from nuclease and protease degradation in biofluids, serving as liquid biopsies.
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Khalife, J., Sanchez, J. F., & Pichiorri, F. (2020). Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools. doi.org. https://doi.org/10.3390/diagnostics10121065

Circulating Exosomal microRNA Signature As a Noninvasive Biomarker for Diagnosis of Diffuse Large B-Cell Lymphoma
2018
Exosomal microRNAs extracted from peripheral blood function effectively as noninvasive diagnostic biomarkers for malignancies such as diffuse large B-cell lymphoma.
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Di, C., Jiang, Y., Li, M., Juan, X., & Xu, C. (2018). Circulating Exosomal microRNA Signature As a Noninvasive Biomarker for Diagnosis of Diffuse Large B-Cell Lymphoma. doi.org. https://doi.org/10.1182/blood-2018-99-115940

Diagnostic accuracy of circulating microRNAs and lipidomic biomarkers for early breast cancer detection: A systematic review and meta-analysis.
2026
Circulating microRNAs demonstrate strong overall diagnostic performance and stability for early breast cancer detection.
Get citation
HM, A., A, A., TADAA, T. D., OM, S., R, J., MM, Y., WZW, Z., & WFWA, R. (2026). Diagnostic accuracy of circulating microRNAs and lipidomic biomarkers for early breast cancer detection: A systematic review and meta-analysis.. doi.org. https://doi.org/10.1371/journal.pone.0354728

Circulating miRNAs for glioblastoma monitoring: from biofluid to clinical decision.
2026
Circulating miRNAs in biofluids show strong potential as minimally invasive liquid biopsy biomarkers for monitoring glioblastoma.
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A, L., E, E., & G, L. (2026). Circulating miRNAs for glioblastoma monitoring: from biofluid to clinical decision.. doi.org. https://doi.org/10.1016/j.omton.2026.201308

Extracellular vesicle-associated and non-vesicle-associated microRNAs for early breast cancer detection: a systematic review.
2026
Circulating microRNAs possess stability in biofluids and cancer-associated dysregulation, making them promising non-invasive biomarkers.
Get citation
JD, R. U., CA, P., MA, I., & Y, P. (2026). Extracellular vesicle-associated and non-vesicle-associated microRNAs for early breast cancer detection: a systematic review.. doi.org. https://doi.org/10.3389/fgene.2026.1716692

What does the evidence say?

Multiple studies and reviews indicate that circulating microRNAs are stable in blood (often protected inside extracellular vesicles or exosomes) and show strong potential as diagnostic and prognostic biomarkers for various cancers.

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