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the claim

Aspirin can cause Reye syndrome in children.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that aspirin can cause Reye syndrome in children?

Yes. Aspirin use in children during viral illnesses is strongly linked to the development of Reye syndrome, a rare but serious condition characterized by encephalopathy and fatty liver failure.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

The analysis

The provided literature and established medical consensus consistently support the link between aspirin (acetylsalicylic acid) administration in children and Reye syndrome, making it a contraindication during viral infections.

Evidence for · 3
Aspirin Use and Reye Syndrome
1987
Discusses the historical epidemiological studies that linked aspirin (salicylates) to Reye syndrome in children.
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KAUFFMAN, R. E. & ROBERTS, R. J. (1987). Aspirin Use and Reye Syndrome. doi.org. https://doi.org/10.1542/peds.79.6.1049

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More for · 2
Aspirin and Reye Syndrome
1988
Notes early clinical observations showing aspirin administration in pediatric patients prior to the onset of Reye syndrome.
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BARAL, J. (1988). Aspirin and Reye Syndrome. doi.org. https://doi.org/10.1542/peds.82.1.135

Potentially Hazardous Drugs in the Paediatric ICU: A Narrative Review on the Exemplary Cases of Propofol, Chloramphenicol, and Acetylsalicylic Acid.
2026
Confirms that acetylsalicylic acid (aspirin) is contraindicated in children due to the risk of Reye's syndrome during viral illnesses.
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L, B., J, V., V, S., J, D. D., E, v. Z., T, P., M, W., & PG, J. (2026). Potentially Hazardous Drugs in the Paediatric ICU: A Narrative Review on the Exemplary Cases of Propofol, Chloramphenicol, and Acetylsalicylic Acid.. doi.org. https://doi.org/10.3390/children13040579

What does the evidence say?

The provided literature and established medical consensus consistently support the link between aspirin (acetylsalicylic acid) administration in children and Reye syndrome, making it a contraindication during viral infections.

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