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the claim

Psychedelic use and mindfulness-style meditation are both associated with changes in the default mode network (DMN) and experiences of ego dissolution.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Psychedelic use and mindfulness-style meditation are both associated with changes in the default mode network (DMN) and experiences of ego dissolution?

Yes. Both psychedelic use and mindfulness-style meditation are robustly linked in contemporary neuroimaging literature to alterations within the brain's default mode network (DMN) and phenomenological experiences of ego dissolution.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the claim that both psychedelics and mindfulness practices engage the default mode network (DMN) and are associated with experiences of ego dissolution or alterations in self-referential processing. Multiple papers (e.g., [0], [3], [6], [9]) explicitly connect psychedelic use and meditation states to DMN modulations and ego dissolution, while papers like [1], [4], and [5] document mindfulness-driven changes to DMN connectivity. No papers refute the claim.

Evidence for · 4
Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects
2019
This study demonstrates that psilocybin combined with mindfulness alters DMN connectivity and specifically links anterior-posterior DMN decoupling to subjective ego dissolution.
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Smigielski, L., Scheidegger, M., Kometer, M., & Vollenweider, F. (2019). Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects. doi.org. https://doi.org/10.1016/j.neuroimage.2019.04.009

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More for · 3
Being no one, being One: The role of ego-dissolution and connectedness in the therapeutic effects of psychedelic experience
2022
This review highlights ego-dissolution as a major therapeutically significant psychological state consistently associated with psychedelic experiences.
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Kałużna, A., Schlosser, M., Craste, E. G., Stroud, J., & Cooke, J. (2022). Being no one, being One: The role of ego-dissolution and connectedness in the therapeutic effects of psychedelic experience. doi.org. https://doi.org/10.1556/2054.2022.00199

Neural Mechanisms and Psychology of Psychedelic Ego Dissolution
2021
This review discusses how psychedelics alter hierarchical brain organization and self-boundary processing, leading to the subjective experience of ego dissolution.
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Stoliker, D., Egan, G. F., Friston, K., & Razi, A. (2021). Neural Mechanisms and Psychology of Psychedelic Ego Dissolution. doi.org. https://doi.org/10.31234/osf.io/aewtm

Psychedelics align brain activity with context.
2026
This study finds that psilocybin reorganizes brain network connectivity to produce self-dissolving and boundary-dissolving experiences in participants.
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D, S., L, N., M, K., M, B., MD, G., T, B., M, W., S, C., O, B., O, S., R, C., FS, B., G, D., KH, P., RL, C., AK, S., S, S., GF, E., & A, R. (2026). Psychedelics align brain activity with context.. doi.org. https://doi.org/10.1038/s41586-026-10910-z

What does the evidence say?

The retrieved literature consistently supports the claim that both psychedelics and mindfulness practices engage the default mode network (DMN) and are associated with experiences of ego dissolution or alterations in self-referential processing. Multiple papers (e.g., [0], [3], [6], [9]) explicitly connect psychedelic use and meditation states to DMN modulations and ego dissolution, while papers like [1], [4], and [5] document mindfulness-driven changes to DMN connectivity. No papers refute the claim.

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