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the claim

Methotrexate is an antifolate drug used in the chemotherapy treatment of acute lymphoblastic leukemia.

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SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

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Is it true that Methotrexate is an antifolate drug used in the chemotherapy treatment of acute lymphoblastic leukemia?

Yes. Methotrexate is a well-established antifolate chemotherapy agent commonly utilized in treatment protocols for acute lymphoblastic leukemia.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

Evidence for · 3
Identification of Risk Factors in High-Dose Methotrexate-Induced Acute Kidney Injury in Childhood Acute Lymphoblastic Leukemia
2018
This study evaluates high-dose methotrexate treatment courses in children with acute lymphoblastic leukemia, noting its effectiveness while investigating associated toxicities.
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Cheng, D., Lu, H., Liu, T., Zou, X., & Pang, H. (2018). Identification of Risk Factors in High-Dose Methotrexate-Induced Acute Kidney Injury in Childhood Acute Lymphoblastic Leukemia. doi.org. https://doi.org/10.1159/000486823

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More for · 2
Role of cystatin C in predicting the risk of hypermethotrexemia and kidney injury after high-dose methotrexate chemotherapy in childhood acute lymphoblastic leukemia.
2026
This study examines high-dose methotrexate chemotherapy outcomes and blood concentrations specifically in pediatric patients undergoing treatment for acute lymphoblastic leukemia.
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W, P., X, Z., LA, D., Z, L., L, S., M, J., X, M., L, D., F, L., X, L., & X, Y. (2026). Role of cystatin C in predicting the risk of hypermethotrexemia and kidney injury after high-dose methotrexate chemotherapy in childhood acute lymphoblastic leukemia.. doi.org. https://doi.org/10.1007/s00277-026-06938-w

Role of cystatin C in predicting the risk of hypermethotrexemia and renal injury after high-dose methotrexate chemotherapy in childhood acute lymphoblastic leukemia
2025
This study analyzes cystatin C levels and methotrexate concentrations following high-dose chemotherapy regimens in children receiving treatment for acute lymphoblastic leukemia.
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Pei, W. (2025). Role of cystatin C in predicting the risk of hypermethotrexemia and renal injury after high-dose methotrexate chemotherapy in childhood acute lymphoblastic leukemia. doi.org. https://doi.org/10.22541/au.176068449.95808472/v1

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