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the claim

Coronary microvascular disease affects the heart's tiny blood vessels and is more common in women.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that coronary microvascular disease affects the heart's tiny blood vessels and is more common in women?

Yes. Coronary microvascular disease affects the tiny blood vessels of the heart and is clinically documented to be more prevalent and manifest differently in women than in men.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

The analysis

The retrieved scientific literature uniformly supports the claim that coronary microvascular disease involves the heart's small vessels and exhibits a higher prevalence and distinct pathophysiology in women.

Evidence for · 4
Sex and gender differences in coronary pathophysiology and ischaemic heart disease.
2026
The scientific statement explicitly outlines functional and structural sex differences, noting that women are more prone to microvascular disease and endothelial dysfunction.
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O, M., D, T., C, A., L, B., R, B., A, C., F, C., G, D. L., A, D., I, D., DJ, D., I, F., E, G., V, K., AR, G., TJ, G., J, M., D, M., D, M., J, P., L, R., A, S., D, T., A, T., M, V., M, Z., E, C., & T, P. (2026). Sex and gender differences in coronary pathophysiology and ischaemic heart disease.. doi.org. https://doi.org/10.1093/eurheartj/ehaf1059

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More for · 3
Coronary Artery Disease in Women: Sex-Specific Pathophysiology, Risk Factors, Clinical Presentation and Management.
2026
This review notes that women are more likely to present with non-obstructive ischemic phenotypes, including coronary microvascular dysfunction.
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KM, N., A, A., M, B., G, B., P, I., N, K., PK, V., P, K., T, T., N, T., N, M., A, P., K, K., I, S., K, T., K, T., & V, P. (2026). Coronary Artery Disease in Women: Sex-Specific Pathophysiology, Risk Factors, Clinical Presentation and Management.. doi.org. https://doi.org/10.3390/medicina62071313

Sex-based differences in invasive assessment of coronary microvascular dysfunction: a systematic review and meta-analysis
2026
A systematic review and meta-analysis demonstrates that women have significantly higher microvascular resistance, lower flow reserve, and a higher overall prevalence of coronary microvascular dysfunction.
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Ramadan, A. (2026). Sex-based differences in invasive assessment of coronary microvascular dysfunction: a systematic review and meta-analysis. doi.org. https://doi.org/10.1093/eurheartjsupp/suag056.029

Coronary microvascular dysfunction in menopausal women.
2026
This clinical review states that coronary microvascular dysfunction is more prevalent in women than men and is prominent in menopausal women.
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D, M., W, W., & V, K. (2026). Coronary microvascular dysfunction in menopausal women.. doi.org. https://doi.org/10.1136/heartjnl-2026-328124

What does the evidence say?

The retrieved scientific literature uniformly supports the claim that coronary microvascular disease involves the heart's small vessels and exhibits a higher prevalence and distinct pathophysiology in women.

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