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the claim

Sertraline use can lead to the development of serotonin syndrome.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Sertraline use can lead to the development of serotonin syndrome?

Yes. Clinical case reports and systematic reviews demonstrate that the use of sertraline, particularly in overdose or combined with other serotonergic agents, can lead to the development of serotonin syndrome.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

The analysis

The retrieved literature contains specific case reports and systematic reviews documenting serotonin syndrome resulting from sertraline use, either alone in overdose or in combination with other drugs. Therefore, the claim is well-supported by the evidence.

Evidence for · 3
Precipitants and clinical features of serotonin syndrome: a systematic review with patient-level analysis of published case reports and series.
2026
A systematic review of serotonin syndrome cases identifies antidepressants, including selective serotonin reuptake inhibitors, as major precipitants.
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B, B., M, D., C, G., C, B., S, T., E, R., E, S., N, K., & G, S. (2026). Precipitants and clinical features of serotonin syndrome: a systematic review with patient-level analysis of published case reports and series.. doi.org. https://doi.org/10.1007/s00228-026-04118-3

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More for · 2
Sertraline and quetiapine induced Serotonin Syndrome and Neuroleptic Malignant Syndrome: a case report.
2026
A clinical case report documents serotonin syndrome following the ingestion of sertraline.
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L, L., ZR, Z., & CF, C. (2026). Sertraline and quetiapine induced Serotonin Syndrome and Neuroleptic Malignant Syndrome: a case report.. doi.org. https://doi.org/10.1186/s12888-026-07862-z

Case Report: Pharmacogenetically-triggered fatal serotonin syndrome following sequential serotonergic therapy in Parkinson's disease: a case highlighting the role of <i>CYP2D6*10/*10</i> genotype and multifactorial drug interactions.
2026
A case report details a fatal case of serotonin syndrome triggered by sequential serotonergic therapy involving sertraline.
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DY, L., YH, Y., N, L., FM, L., & WJ, G. (2026). Case Report: Pharmacogenetically-triggered fatal serotonin syndrome following sequential serotonergic therapy in Parkinson's disease: a case highlighting the role of <i>CYP2D6*10/*10</i> genotype and multifactorial drug interactions.. doi.org. https://doi.org/10.3389/fpsyt.2026.1750596

What does the evidence say?

The retrieved literature contains specific case reports and systematic reviews documenting serotonin syndrome resulting from sertraline use, either alone in overdose or in combination with other drugs. Therefore, the claim is well-supported by the evidence.

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