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the claim

Abnormal expression of specific microRNAs is implicated in the pathogenesis of various human cancers.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
6 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that abnormal expression of specific microRNAs is implicated in the pathogenesis of various human cancers?

Yes. Extensive scientific literature demonstrates that the abnormal expression of specific microRNAs is directly implicated in the pathogenesis, progression, and therapeutic resistance of numerous human cancers.

Verdict: SUPPORTED · 6 sources for, 0 against · Last checked

The analysis

The retrieved papers consistently support the claim that microRNA dysregulation plays a critical role in various human cancers, acting as either oncogenes or tumor suppressors across multiple malignancies. The evidence strongly favors the claim without refutation.

Evidence for · 6
The paradox of miR-107 in oncology: dual roles as a tumor suppressor and oncomiR.
2026
Reviews how miR-107 acts as either a tumor suppressor or oncomiR depending on context, demonstrating that microRNA dysregulation drives oncogenic phenotypes.
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MA, R., N, F., YM, A., EA, A., & SA, F. (2026). The paradox of miR-107 in oncology: dual roles as a tumor suppressor and oncomiR.. doi.org. https://doi.org/10.1038/s41417-026-01042-7

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More for · 5
microRNA-155: a versatile noncoding RNA.
2026
Details how aberrant expression of microRNA-155 contributes to tumorigenesis by modulating tumor suppressor genes in various cancers.
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PSS, A., MP, A., & KMH, P. (2026). microRNA-155: a versatile noncoding RNA.. doi.org. https://doi.org/10.1007/s11033-026-11706-0

MicroRNA Dysregulation in HPV-Driven Cervical Cancer: A Review of Oncoprotein-Targeted Signaling Pathways.
2026
Highlights how deregulated microRNA expression in cervical cancer interferes with key molecular pathways to drive tumor aggressiveness.
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GM, P., S, C., PRD, S., AJA, F., SMJ, B., RM, R., MMC, M., & RL, C. (2026). MicroRNA Dysregulation in HPV-Driven Cervical Cancer: A Review of Oncoprotein-Targeted Signaling Pathways.. doi.org. https://doi.org/10.3390/life16081332

Bioinformatics Analysis of microRNAs Associated with Metastatic Potential in Breast Cancer.
2026
Links microRNA dysregulation in breast cancer to tumor initiation, progression, and metastasis.
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A, N., S, G., J, S., M, B., O, N., J, J., & Z, D. (2026). Bioinformatics Analysis of microRNAs Associated with Metastatic Potential in Breast Cancer.. doi.org. https://doi.org/10.3390/biology15080617

Emerging Roles of MicroRNAs in Diffuse Large B-Cell Lymphoma: From Molecular Mechanisms to Clinical Translation, Liquid Biopsy, and Precision Medicine.
2026
Notes that specific miRNAs act as oncogenes or tumor suppressors in diffuse large B-cell lymphoma, influencing tumor survival and progression.
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C, J., L, J., O, M., M, O., B, F., & M, Z. (2026). Emerging Roles of MicroRNAs in Diffuse Large B-Cell Lymphoma: From Molecular Mechanisms to Clinical Translation, Liquid Biopsy, and Precision Medicine.. doi.org. https://doi.org/10.3390/biomedicines14091904

The Promise and Pursuit of MicroRNAs for Cancer Treatment.
2026
Explains how microRNAs can be overexpressed as oncogenes or underexpressed as tumor suppressors to control aspects of cancer.
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C, B., A, R., J, K., & JJ, L. (2026). The Promise and Pursuit of MicroRNAs for Cancer Treatment.. doi.org. https://doi.org/10.3390/biom16081086

What does the evidence say?

The retrieved papers consistently support the claim that microRNA dysregulation plays a critical role in various human cancers, acting as either oncogenes or tumor suppressors across multiple malignancies. The evidence strongly favors the claim without refutation.

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