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the claim

Amyotrophic lateral sclerosis symptom spread occurs faster in contiguous areas of the nervous system than in non-contiguous areas.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that amyotrophic lateral sclerosis symptom spread occurs faster in contiguous areas of the nervous system than in non-contiguous areas?

Yes. Clinical evidence demonstrates that amyotrophic lateral sclerosis symptom spread preferentially follows a contiguous pattern through adjacent areas of the nervous system.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

The analysis

The retrieved literature, particularly large-scale cohort studies like those by [0] and [2], robustly confirms that disease propagation in amyotrophic lateral sclerosis predominantly occurs in contiguous or adjacent regions from the site of symptom onset.

Evidence for · 2
Spreading in ALS: The relative impact of upper and lower motor neuron involvement.
2020
The study of 1,376 patients found that disease progression was more likely and quicker to or from the region of onset to close spinal regions, establishing contiguous progression as the leading pattern.
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M, G., M, F., H, U., J, G., M, K., S, P., S, P., S, M., M, S., & M, d. C. (2020). Spreading in ALS: The relative impact of upper and lower motor neuron involvement.. doi.org. https://doi.org/10.1002/acn3.51098

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More for · 1
Regional spreading pattern is associated with clinical phenotype in amyotrophic lateral sclerosis.
2023
The study demonstrated that the most frequent initial spreading pattern was towards adjacent horizontal regions, confirming preferential contiguous spread.
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A, M., F, V., E, C., B, P., A, D., R, B., D, G., M, M., L, M., S, M., S, C., C, M., V, S., & N, T. (2023). Regional spreading pattern is associated with clinical phenotype in amyotrophic lateral sclerosis.. doi.org. https://doi.org/10.1093/brain/awad129

What does the evidence say?

The retrieved literature, particularly large-scale cohort studies like those by [0] and [2], robustly confirms that disease propagation in amyotrophic lateral sclerosis predominantly occurs in contiguous or adjacent regions from the site of symptom onset.

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