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the claim

St John's wort reduces symptoms of anxiety.

the verdict
REFUTED
the evidence says no
Recorded sources
1 source for · 4 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that St John's wort reduces symptoms of anxiety?

No. One source directly addressing St John's wort for anxiety reports insufficient evidence of effectiveness and no clear benefit over placebo, while other placed sources discuss only depression or traditional use and do not establish anxiety reduction.

Verdict: REFUTED · 1 source for, 4 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 1
Preventing Neurons and Glial Cells Destruction in Substantia Nigra Pars Compacta and Striatum Using St. John's Wort and Stem Cells on Parkinson's Model.
2025
Get citation
H, F., H, S., A, G., AA, V., A, K., M, M., L, G., A, S., & M, S. (2025). Preventing Neurons and Glial Cells Destruction in Substantia Nigra Pars Compacta and Striatum Using St. John's Wort and Stem Cells on Parkinson's Model.. doi.org. https://doi.org/10.1002/brb3.71124

Evidence against · 4
St. John's wort.
2005
Get citation
Lawvere, S. & Mahoney, M. C. (2005). St. John's wort.. pubmed.ncbi.nlm.nih.gov. https://pubmed.ncbi.nlm.nih.gov/16342849/

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More against · 3
St John’s Wort for Anxiety .What Does the UK Evidence Actually Say?
2026
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St John’s Wort for Anxiety.What Does the UK Evidence Actually Say?. (2026). medicalsciences.stackexchange.com. https://medicalsciences.stackexchange.com/questions/34931/st-john-s-wort-for-anxiety-what-does-the-uk-evidence-actually-say

The efficacy and safety of St. John's wort extract in depression therapy compared to SSRIs in adults: A meta-analysis of randomized clinical trials.
2023
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Zhao, X., Zhang, H., Wu, Y., & Yu, C. (2023). The efficacy and safety of St. John's wort extract in depression therapy compared to SSRIs in adults: A meta-analysis of randomized clinical trials.. doi.org. https://doi.org/10.17219/acem/152942

The role of diet in managing menopausal symptoms: A narrative review.
2023
Get citation
Yelland, S., Steenson, S., Creedon, A., & Stanner, S. (2023). The role of diet in managing menopausal symptoms: A narrative review.. doi.org. https://doi.org/10.1111/nbu.12607

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