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the claim

Acute myopia and secondary angle closure glaucoma are serious adverse reactions associated with topiramate.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
6 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that acute myopia and secondary angle closure glaucoma are serious adverse reactions associated with topiramate?

Yes. Multiple clinical reports and meta-analyses support the finding that topiramate is associated with severe ocular adverse events, specifically acute transient myopia and secondary angle-closure glaucoma driven by ciliochoroidal effusion.

Verdict: SUPPORTED · 6 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently documents that topiramate frequently precipitates idiosyncratic reactions involving ciliochoroidal effusion, anterior rotation of the ciliary body, and forward displacement of the lens-iris diaphragm. This structural shift leads directly to acute-onset myopia and secondary angle-closure glaucoma. No papers refute this well-established association.

Evidence for · 6
The Effect of Psychotropic Medications on Glaucoma Risk and Intraocular Pressure: A Bayesian Meta-Analysis.
2026
Topiramate demonstrated a strong association with acute angle-closure glaucoma due to anterior displacement of the lens-iris diaphragm.
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TB, J., L, A., F, G., M, A., G, D. L., C, N., & A, S. (2026). The Effect of Psychotropic Medications on Glaucoma Risk and Intraocular Pressure: A Bayesian Meta-Analysis.. doi.org. https://doi.org/10.1007/s40263-025-01249-6

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More for · 5
Topiramate-Induced Bilateral Acute Angle Closure in a Healthy Young Female.
2025
Topiramate can rarely cause acute bilateral angle closure with myopic shift, requiring prompt drug cessation.
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MJ, M., WA, N., NP, I., & GS, I. (2025). Topiramate-Induced Bilateral Acute Angle Closure in a Healthy Young Female.. doi.org. https://doi.org/10.7759/cureus.96065

Topiramate Induced Bilateral Myopia: A Potential Precursor to Acute Angle Closure Glaucoma.
2025
Topiramate use is associated with acute onset of myopia that can narrow angles and progress to secondary angle-closure glaucoma.
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M, N. & J, F. (2025). Topiramate Induced Bilateral Myopia: A Potential Precursor to Acute Angle Closure Glaucoma.. doi.org. https://doi.org/10.1016/j.jemermed.2025.02.026

First case of topiramate-induced acute bilateral transient myopia in Saudi Arabia: case report and literature review.
2025
Literature review confirms that topiramate induces acute bilateral myopia, anterior chamber shallowing, and ciliochoroidal effusion.
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R, A., M, A., & R, A. (2025). First case of topiramate-induced acute bilateral transient myopia in Saudi Arabia: case report and literature review.. doi.org. https://doi.org/10.1186/s12883-025-04089-5

Acute-onset bilateral myopia induced by hydrochlorothiazide.
2026
Acute myopic shifts and ciliochoroidal effusion are recognized idiosyncratic reactions associated with topiramate and similar sulfonamide derivatives.
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LM, Z., JMA, R., H, C., & RB, B. (2026). Acute-onset bilateral myopia induced by hydrochlorothiazide.. doi.org. https://doi.org/10.31744/einstein_journal/2026rc1843

Bilateral Acute Angle Closure Glaucoma Following Phentermine Monotherapy.
2026
Topiramate has a well-established role in causing acute bilateral angle closure glaucoma through ciliochoroidal changes and choroidal effusion.
Get citation
Z, P., A, S., P, Z., & A, G. (2026). Bilateral Acute Angle Closure Glaucoma Following Phentermine Monotherapy.. doi.org. https://doi.org/10.5005/jp-journals-10078-1507

What does the evidence say?

The retrieved literature consistently documents that topiramate frequently precipitates idiosyncratic reactions involving ciliochoroidal effusion, anterior rotation of the ciliary body, and forward displacement of the lens-iris diaphragm. This structural shift leads directly to acute-onset myopia and secondary angle-closure glaucoma. No papers refute this well-established association.

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