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the claim

Mirtazapine use can lead to increased appetite and weight gain.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
6 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Mirtazapine use can lead to increased appetite and weight gain?

Yes. Multiple clinical sources confirm that mirtazapine use frequently leads to increased appetite and weight gain, largely driven by its pharmacological profile including histamine H-1 receptor antagonism.

Verdict: SUPPORTED · 6 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently links mirtazapine use to increased appetite and subsequent weight gain across various patient populations and settings. The evidence supporting this well-established adverse effect/therapeutic side effect is robust, with zero contradictory papers provided.

Evidence for · 6
Carbohydrate Craving and Increased Appetite Associated with Antidepressant Therapy
1988
Identifies histamine H-1 receptor blockade from antidepressant therapy as an important factor in carbohydrate craving and increased appetite.
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Yeragani, V. K., Pohl, R., Aleem, A., Balon, R., Sherwood, P., & Lycaki, H. (1988). Carbohydrate Craving and Increased Appetite Associated with Antidepressant Therapy. doi.org. https://doi.org/10.1177/070674378803300706

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More for · 5
Antidepressant prescribing patterns and patient-reported adverse effects: a cross-sectional study from Pakistan.
2026
Associates atypical antidepressants and combination therapies including mirtazapine with metabolic effects such as weight gain.
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S, R., F, K., A, K., A, J., S, I., G, A., SS, A., & BA, A. (2026). Antidepressant prescribing patterns and patient-reported adverse effects: a cross-sectional study from Pakistan.. doi.org. https://doi.org/10.1186/s12991-026-00644-7

Practical prescribing in cancer cachexia.
2026
Notes that low-level evidence exists for mirtazapine leading to appetite stimulation and weight gain in supportive care contexts.
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D, M., J, C., & J, D. (2026). Practical prescribing in cancer cachexia.. doi.org. https://doi.org/10.1097/spc.0000000000000814

Mirtazapine-Induced Bicytopenia in a Patient With Multifactorial Delirium: A Case Report.
2026
Indicates that weight gain is a common and favorable side effect often utilized in geriatric patients prescribed mirtazapine.
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BG, Y. & A, B. (2026). Mirtazapine-Induced Bicytopenia in a Patient With Multifactorial Delirium: A Case Report.. doi.org. https://doi.org/10.7759/cureus.107522

[Psychotropic drug-induced obesity in older adults: complications, preventive and therapeutic interventions].
2026
Classifies mirtazapine alongside other psychotropic agents strongly associated with significant weight gain and obesity via H1 blockade and metabolic mechanisms.
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G, N., G, V., & B, S. (2026). [Psychotropic drug-induced obesity in older adults: complications, preventive and therapeutic interventions].. doi.org. https://doi.org/10.1556/650.2026.33499

Mirtazapine for the treatment of irritable bowel syndrome: A systematic review.
2026
Reports weight gain as a clinical observation in patients treated with mirtazapine.
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R, P. & J, S. (2026). Mirtazapine for the treatment of irritable bowel syndrome: A systematic review.. doi.org. https://doi.org/10.5662/wjm.v16.i1.107908

What does the evidence say?

The retrieved literature consistently links mirtazapine use to increased appetite and subsequent weight gain across various patient populations and settings. The evidence supporting this well-established adverse effect/therapeutic side effect is robust, with zero contradictory papers provided.

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