trustmebro.to/r/…
✓ checked
trust me, bro:
here is the receipt.
the claim

The prevalence of the HLA DR4 antigen is increased in patients with rheumatoid arthritis.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that the prevalence of the HLA DR4 antigen is increased in patients with rheumatoid arthritis?

Yes. The prevalence and genetic contribution of the HLA-DR4 antigen (and related HLA-DRB1*04 alleles) are strongly associated with increased susceptibility to rheumatoid arthritis.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the well-established immunological finding that HLA-DR4 (and corresponding HLA-DRB1 alleles) confers significant genetic susceptibility to rheumatoid arthritis. Papers 1 and 3 explicitly discuss the association of DR4/HLA-DRB1*04 risk alleles with rheumatoid arthritis pathogenesis. There are no papers refuting this established genetic association.

Evidence for · 2
The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity.
2025
Identifies ancestral HLA-II haplotypes, including DR4-DQ8, as playing a central role in susceptibility to autoimmune diseases such as rheumatoid arthritis.
Get citation
M, R., B, P., & A, Z. (2025). The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity.. doi.org. https://doi.org/10.3389/fimmu.2025.1710571

See more details
More for · 1
HLA-DR risk variants in rheumatoid arthritis: what we know and still do not know.
2026
Confirms that rheumatoid arthritis susceptibility is strongly influenced by genetic variations within the major histocompatibility complex, noting that the shared epitope hypothesis explains the clustering of susceptibility within HLA-DRB1*04 subtypes.
Get citation
CF, Y. & S, V. (2026). HLA-DR risk variants in rheumatoid arthritis: what we know and still do not know.. doi.org. https://doi.org/10.1136/rmdopen-2025-006045

Receipt History
Anyone with this link can read the claim and its public receipt, including any personal information in that text. Open permanent receipt.
Check your own claim
Challenge the receipt
Requests are recorded for review. This does not start an automatic check or guarantee a response time.

See the evidence timeline

Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.

This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work