Children taking immunosuppressant drugs are more susceptible to infections than healthy children.
Is it true that children taking immunosuppressant drugs are more susceptible to infections than healthy children?
Yes. Clinical evidence consistently demonstrates that children taking immunosuppressant drugs have heightened susceptibility to opportunistic and bacterial infections due to diminished immune surveillance.
Verdict: SUPPORTED · 8 sources for, 0 against · Last checked
The claim is specific, empirical, and well-supported by multiple clinical studies involving pediatric populations on immunosuppressive regimens (e.g., transplant recipients, inflammatory bowel disease patients, and those on therapy for autoimmune diseases) who experience increased rates of infections.
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A, G., T, A., Z, A., N, B., AB, R., A, B., M, B., E, C., H, d. J., J, D., A, D., F, E., A, F., S, F., ML, G., B, G., C, G., J, H., B, H., S, J., N, K., JJ, K., U, K., R, L., M, L., S, M., A, M., G, N., L, O., J, O., N, P., A, P., C, P., M, P., E, P., A, P., S, R., M, S., R, S., T, S., J, S., S, T., B, T., DD, T., LT, W., M, N., & L, P. (2026). Evidence- and Consensus-based European Guideline for Immunosuppressive Therapy After Pediatric Kidney Transplantation.. doi.org. https://doi.org/10.1097/tp.0000000000005772
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Z, W., C, L., Y, Z., X, D., W, H., & Q, C. (2026). Clinical Characteristics and Antimicrobial Resistance Profiles of Pediatric Enterococcal Infections: A Comparison Between <i>Enterococcus faecium</i> and <i>Enterococcus faecalis</i>.. doi.org. https://doi.org/10.3390/pathogens15090927
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RE, G., R, L., ME, N., JK, D., JC, C., & DT, C. (2026). Disseminated Varicella Zoster and Multiorgan Failure Requiring ECMO Support in a Patient With Evans Syndrome.. doi.org. https://doi.org/10.1155/crcc/2103304
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T, M., M, Y., K, S., T, F., M, J., H, U., A, F., S, S., M, K., & C, O. (2026). Aeromonas Bacteremia in Pediatric Liver Transplant Recipients: Case-Based Experience of an Under-Recognized Infection.. doi.org. https://doi.org/10.1111/petr.70407
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C, E., U, C., E, K. T., K, C., M, Y. D., SE, K., G, G. O., G, O., N, K., E, A., G, T., M, K., A, C., DY, M., G, A., & Z, S. B. (2026). Clinical Characteristics, Management, and 30-Day Mortality Predictors in an 18-Year Pediatric Candidemia Cohort.. doi.org. https://doi.org/10.3390/jof12060445
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RM, P., AC, H., S, B., & B, K. (2026). Bacterial Gastrointestinal Infections in Pediatric Inflammatory Bowel Disease (PIBD)-A Single-Center Experience of Epidemiology, Management, and Outcome.. doi.org. https://doi.org/10.3390/diagnostics16091411
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LE, L. P., AM, P. V., MR, R. R., SE, R. M., & ST, M. M. (2026). Fulminant disseminated histoplasmosis in a pediatric patient with ataxia-telangiectasia and autoimmune hepatitis: A diagnostic and therapeutic challenge.. doi.org. https://doi.org/10.1016/j.idcr.2026.e02704
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A, K., J, D., V, K., E, P., C, A., G, M., L, S., D, Z., G, T., G, G., G, P., & N, P. (2026). Timing and Clinical Impact of Opportunistic Infections in Pediatric Kidney Transplant Recipients: A 10-Year Single-Center Experience.. doi.org. https://doi.org/10.3390/jcm15124668
What does the evidence say?
The claim is specific, empirical, and well-supported by multiple clinical studies involving pediatric populations on immunosuppressive regimens (e.g., transplant recipients, inflammatory bowel disease patients, and those on therapy for autoimmune diseases) who experience increased rates of infections.
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