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the claim
Some individuals with Alport nephropathy do not experience hearing loss.
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SUPPORTED
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2 sources for · 0 against
Is it true that some individuals with Alport nephropathy do not experience hearing loss?
Yes. Clinical studies of Alport syndrome consistently demonstrate that extrarenal manifestations like sensorineural hearing loss are variable and absent in a significant portion of affected individuals.
Verdict: SUPPORTED · 2 sources for, 0 against · Last checked
Evidence for · 2
This study demonstrates that not all children with Alport syndrome present with hearing impairment, noting that only a subset (18%) developed hearing loss during the study period.
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Boeckhaus, J., Strenzke, N., Storz, C., & Gross, O. (2020). Characterization of Sensorineural Hearing Loss in Children with Alport Syndrome. doi.org. https://doi.org/10.3390/life10120360
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More for · 1
This study reports that hearing loss occurred in only 34% of patients carrying the COL4A3 variant, indicating that many individuals with Alport syndrome do not experience hearing loss.
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AM, G., CF, R., J, D., PM, M., N, M., G, F., V, F., J, M., C, L., D, L., & I, B. (2026). Clinical Insights Into the COL4A3 p.Gly407Arg Variant in Alport Syndrome.. doi.org. https://doi.org/10.34067/kid.0000001184
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