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the claim

SSRI antidepressants cause weight loss.

the verdict
CONTESTED PARTIAL
Recorded sources
2 sources for · 6 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that SSRI antidepressants cause weight loss?

Partly. Several reviews and cohort studies associate SSRI antidepressants with weight gain or no weight difference rather than loss, while one rat study and one consumer-health page suggest SSRIs or antidepressants can be linked to weight loss. The evidence is mixed and largely indirect, so it only partially addresses whether SSRIs cause weight loss.

Verdict: CONTESTED PARTIAL · 2 sources for, 6 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 2
Facebook
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Facebook. (n.d.). health.clevelandclinic.org. https://health.clevelandclinic.org/can-antidepressants-cause-weight-loss

Evidence against · 6
Which Antidepressants Cause the Most Weight Gain?
2025
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Zarkowski, P. (2025). Which Antidepressants Cause the Most Weight Gain?. doi.org. https://doi.org/10.64239/pi-qt7202

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More for · 1
Selective Serotonin Re-uptake Inhibitors (SSRIs) Induced Weight Changes: A Dose and Duration Dependent Study on Albino Rats
2016
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Selective Serotonin Re-uptake Inhibitors (SSRIs) Induced Weight Changes: A Dose and Duration Dependent Study on Albino Rats. (2016). doi.org. https://doi.org/10.7860/jcdr/2016/16482.7376

More against · 5
The Association of Antidepressant Medication and Body Weight Gain.
2013
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Ranjbar, S., Pai, N. B., & Deng, C. (2013). The Association of Antidepressant Medication and Body Weight Gain.. ojhas.org. http://ojhas.org/issue45/2013-1-1.html

The Association of Antidepressant Medication and Body Weight Gain.
2013
Get citation
The Association of Antidepressant Medication and Body Weight Gain.. (2013). doaj.org. https://doaj.org/article/5cd49583a57749f29806b5566e7b8ceb

Weight Outcomes Among Antidepressant Users in Nursing Facilities
2001
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Weight Outcomes Among Antidepressant Users in Nursing Facilities. (2001). doi.org. https://doi.org/10.1046/j.1532-5415.2001.49009.x

Medications that cause weight gain and alternatives in Canada: a narrative review
2018
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Wharton, S., Raiber, L., Serodio, K., Lee, J., & Christensen, R. (2018). Medications that cause weight gain and alternatives in Canada: a narrative review. doi.org. https://doi.org/10.2147/DMSO.S171365

Impact of selective serotonin reuptake inhibitors on weight loss after vertical sleeve gastrectomy.
2024
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Mushtaq, B., Galantini, G., Ottaway, J., Perrotti, G., Myers, R., Taylor, N., McDonnough, J., Walker, J., Medrano, G., Chipman, C., Noonan, K. M., & Antanavicius, G. (2024). Impact of selective serotonin reuptake inhibitors on weight loss after vertical sleeve gastrectomy.. doi.org. https://doi.org/10.1016/j.soard.2024.07.017

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