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Advanced paternal age increases the risk of autism in children.
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SUPPORTED
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8 sources for · 0 against
Is it true that advanced paternal age increases the risk of autism in children?
Yes. A 27-study meta-analysis reports that a 10-year increase in paternal age is associated with about a 21% higher risk of autism, and several reviews and population studies likewise report an association between advanced paternal age and autism risk.
Verdict: SUPPORTED · 8 sources for, 0 against · Last checked
Evidence for · 8
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Paternal age effect. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Paternal_age_effect
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More for · 7
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AM, N. A. & SK, U. (2017). Is advanced paternal age a health risk for the offspring?. doi.org. https://doi.org/10.1016/j.fertnstert.2016.12.019
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Sasanfar, R., Haddad, S. A., Tolouei, A., Ghadami, M., Yu, D., & Santangelo, S. L. (2010). Paternal age increases the risk for autism in an Iranian population sample. doi.org. https://doi.org/10.1186/2040-2392-1-2
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Advanced paternal age as a risk factor for autism spectrum disorder in a Mexican population. (2020). doi.org. https://doi.org/10.17711/sm.0185-3325.2020.016
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Wu, S., Wu, F., Ding, Y., Hou, J., Bi, J., & Zhang, Z. (2017). Advanced parental age and autism risk in children: a systematic review and meta-analysis.. doi.org. https://doi.org/10.1111/acps.12666
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Balkom, I. D. C. v., Bresnahan, M., Vuijk, P. J., Hubert, J., Susser, E., & Hoek, H. W. (2012). Paternal Age and Risk of Autism in an Ethnically Diverse, Non-Industrialized Setting: Aruba. doi.org. https://doi.org/10.1371/journal.pone.0045090
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Patki, A. & Hinduja, R. (2025). Advanced Paternal Age and Its Impact on Reproductive and Offspring Health: Integrating Evidence from Clinical and Translational Studies. doi.org. https://doi.org/10.1142/s2661318225300041
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Saha, S., Barnett, A. G., Foldi, C., Burne, T. H., Eyles, D. W., & Buka, S. L. (2009). Advanced Paternal Age Is Associated with Impaired Neurocognitive Outcomes during Infancy and Childhood. doi.org. https://doi.org/10.1371/journal.pmed.1000040
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