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the claim
Magnesium sulfate administration increases the risk of postpartum hemorrhage.
the verdict
CONTESTED PARTIAL
Recorded sources
2 sources for · 2 against
Is it true that magnesium sulfate administration increases the risk of postpartum hemorrhage?
Partly. One cohort reports increased odds of postpartum hemorrhage with intrapartum magnesium sulfate in hypertensive pregnancies, while a mechanistic review calls the hemorrhagic associations mixed; two other studies found no significant increase in blood loss or postpartum hemorrhage. The evidence is partial and points in both directions.
Verdict: CONTESTED PARTIAL · 2 sources for, 2 against · Last checked
Evidence for · 2
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Association between Receipt of Intrapartum Magnesium Sulfate and Postpartum Hemorrhage - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1055/s-0040-1721671
Evidence against · 2
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Schoen, C. N., Graham, N. M., Corlin, T., Knee, A., Berghella, V., & Roman, A. (2021). Calculated blood loss at cesarean delivery in patients with preeclampsia with severe features on magnesium sulfate. doi.org. https://doi.org/10.1080/14767058.2021.1961729
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More for · 1
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Bouya, M. S., Hamdani, Z., & Bouhabba, N. (2026). Magnesium Sulfate, Nicardipine, and Volatile Anesthetics in Severe Preeclampsia: Clinical and Mechanistic Implications for Uterine Atony and Postpartum Hemorrhage. doi.org. https://doi.org/10.1097/fm9.0000000000000372
More against · 1
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Bansal, V. & Desai, A. (2021). Efficacy of Antenatal Magnesium Sulfate for Neuroprotection in Extreme Prematurity: A Comparative Observational Study. doi.org. https://doi.org/10.1007/s13224-021-01531-9
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