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the claim
The JAK2V617F mutation is caused by a G-to-T transversion in the Janus Kinase 2 gene resulting in a valine-to-phenylalanine amino acid substitution at codon 617.
the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against
Is it true that the JAK2V617F mutation is caused by a G-to-T transversion in the Janus Kinase 2 gene resulting in a valine-to-phenylalanine amino acid substitution at codon 617?
Yes. The retrieved scientific literature consistently supports that the JAK2V617F mutation stems from a G-to-T transversion in the Janus kinase 2 gene, causing a valine-to-phenylalanine substitution at codon 617.
Verdict: SUPPORTED · 2 sources for, 0 against · Last checked
Evidence for · 2
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DG, T., J, P., AG, d. C., A, M., GV, S., LPS, M., & AM, T. (2022). <i>JAK2</i> Variant Signaling: Genetic, Hematologic and Immune Implication in Chronic Myeloproliferative Neoplasms.. doi.org. https://doi.org/10.3390/biom12020291
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More for · 1
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Shide, K., Nakaya, Y., Kameda, T., Shimoda, H., Hidaka, T., Kubuki, Y., Katayose, K., Matsunaga, T., Homan, J., Kotera, T., Shibayama, H., Naito, H., & Shimoda, K. (2010). NS-018, a Potent Novel JAK2 Inhibitor, Effectively Treats Murine MPN Induced by the Janus Kinase 2 (JAK2) V617F Mutant. doi.org. https://doi.org/10.1182/blood.v116.21.4106.4106
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