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the claim

Grapefruit juice interacts with many common medications by inhibiting the intestinal CYP3A4 enzyme.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
10 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Grapefruit juice interacts with many common medications by inhibiting the intestinal CYP3A4 enzyme?

Yes. Multiple sources, including the FDA and peer-reviewed reviews, state that grapefruit juice blocks intestinal CYP3A4, the enzyme that metabolizes many common drugs, thereby raising drug levels. The claim is directly supported.

Verdict: SUPPORTED · 10 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 10
Grapefruits and CYP3A4
2015
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Grapefruits and CYP3A4. (2015). biology.stackexchange.com. https://biology.stackexchange.com/questions/27757/grapefruits-and-cyp3a4

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More for · 9
Grapefruit Juice and Some Drugs Don't Mix | FDA
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Grapefruit Juice and Some Drugs Don't Mix | FDA. (n.d.). fda.gov. https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix

Grapefruit–medication interactions: Forbidden fruit or avoidable consequences? -
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Grapefruit–medication interactions: Forbidden fruit or avoidable consequences? - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1503/cmaj.120951

CYP3A4
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CYP3A4. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/CYP3A4

Plant-drug Interactions: Mechanisms and Clinical Implications of Cytochrome P450 Modulation by Common Phytochemicals
2025
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Plant-drug Interactions: Mechanisms and Clinical Implications of Cytochrome P450 Modulation by Common Phytochemicals. (2025). hal.science. https://hal.science/hal-05211755v1

Grapefruit juice–drug interactions
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Grapefruit juice–drug interactions. (n.d.). cir.nii.ac.jp. https://doi.org/10.1046/j.1365-2125.1998.00764.x

Variation in Furanocoumarin Content and New Furanocoumarin Dimers in Commercial Grapefruit ( Citrus paradisi Macf.) Juices
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Variation in Furanocoumarin Content and New Furanocoumarin Dimers in Commercial Grapefruit ( Citrus paradisi Macf.) Juices. (n.d.). cir.nii.ac.jp. https://doi.org/10.1111/j.1365-2621.2005.tb07178.x

What You Should Know About Medicines/The Most Common Drug Interactions
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What You Should Know About Medicines/The Most Common Drug Interactions. (n.d.). en.wikibooks.org. https://en.wikibooks.org/wiki/What_You_Should_Know_About_Medicines/The_Most_Common_Drug_Interactions

Grapefruit–drug interactions
Get citation
Grapefruit–drug interactions. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions

Take your medicine with water: common fruit juice-drug interactions
2024
Get citation
Damir, P., Maja, M., & Jelena, J. (2024). Take your medicine with water: common fruit juice-drug interactions. zenodo.org. https://doi.org/10.5281/zenodo.14024719

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