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the claim
Excess visceral fat disrupts hormone levels, including insulin, leptin, and sex hormones.
the verdict
INSUFFICIENT LEANING
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8 sources for · 0 against
Is it true that excess visceral fat disrupts hormone levels, including insulin, leptin, and sex hormones?
Unclear. Several studies in rodents and obese humans report that excess visceral or central fat is accompanied by altered insulin and leptin levels, and one human study found correlations with testosterone, estradiol and DHEA-S. None of the placed items covers the full claim across all three hormone groups at the strength asserted.
Verdict: PARTIAL LEAN · 8 sources for, 0 against · Last checked
Evidence for · 8
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Rasmussen, D. D., Boldt, B. M., Wilkinson, C., Yellon, S. M., & Matsumoto, A. M. (1999). Daily Melatonin Administration at Middle Age Suppresses Male Rate Visceral Fat, Plasma Leptin, and Plasma Insulin to Youthful Levels. doi.org. https://doi.org/10.1210/endo.140.2.6674
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More for · 7
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Garaulet, M., Perex-Llamas, F., Fuente, T., Zamora, S., & Tebar, F. (2000). Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones. doi.org. https://doi.org/10.1530/eje.0.1430657
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I, G., XH, M., XM, Y., G, A., MW, R., AH, B., P, S., L, R., & N, B. (2002). Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?. doi.org. https://doi.org/10.2337/diabetes.51.10.2951
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M, M. V., B, Q., J, P., A, O., B, F., A, S. H., MJ, S., C, G., E, M., & MA, B. (2026). Visceral Adiposity and Renal Health: From Pathophysiological Mechanisms to Novel Therapeutic Strategies.. doi.org. https://doi.org/10.3390/jcm15187201
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Obesity, estrogens and adipose tissue dysfunction – implications for pulmonary arterial hypertension - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.1177/2045894020952023
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Visceral Adiposity Index and Leptin Levels in Type 2 Diabetics in Port Harcourt: Effects of Disease Duration and Sex. (2025). hal.science. https://doi.org/10.9734/ajrimps/2025/v14i3317
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Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women.. (2006). hal.science. https://doi.org/10.1016/j.bbrc.2006.07.068
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C, A., P, C., C, T., F, R., & P, M. (2004). Changes in glycemia by leptin administration or high- fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis.. doi.org. https://doi.org/10.1210/en.2003-1679
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