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the claim

Antidepressants such as SSRIs increase the risk of bleeding.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
10 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that antidepressants such as SSRIs increase the risk of bleeding?

Yes. Multiple peer-reviewed reviews and pharmacovigilance analyses report that SSRIs increase bleeding risk, with several concluding this is a class-wide concern; some studies cover only SSRI use combined with anticoagulants or NSAIDs.

Verdict: SUPPORTED · 10 sources for, 0 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 10
SSRIs and Bleeding Risk: What Does the Evidence Say?
2018
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SSRIs and Bleeding Risk: What Does the Evidence Say?. (2018). doi.org. https://doi.org/10.64239/pi-vl0504

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More for · 9
Antidepressants and Risk of Upper Gastrointestinal Bleeding
2006
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Antidepressants and Risk of Upper Gastrointestinal Bleeding. (2006). doi.org. https://doi.org/10.1111/j.1742-7843.2006.pto_303.x

Do SSRIs Increase Major Bleeding Risk with Oral Anticoagulants?
2025
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Zarkowski, P. (2025). Do SSRIs Increase Major Bleeding Risk with Oral Anticoagulants?. doi.org. https://doi.org/10.64239/pi-qt7703

Bleeding risk from antidepressants in patients with atrial fibrillation
2020
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Bleeding risk from antidepressants in patients with atrial fibrillation. (2020). doi.org. https://doi.org/10.1002/pu.30616

Review of gastrointestinal bleeding during use of SSRIs combined with use of NSAID
2022
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Arts, M., Petrykiv, S., & Jonge, L. D. (2022). Review of gastrointestinal bleeding during use of SSRIs combined with use of NSAID. doi.org. https://doi.org/10.1192/j.eurpsy.2022.439

Serotonin Reuptake Inhibitor Antidepressants and Abnormal Bleeding
2010
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Serotonin Reuptake Inhibitor Antidepressants and Abnormal Bleeding. (2010). doi.org. https://doi.org/10.4088/jcp.09r05786blu

Major Bleeding Risk in Patients With Non-valvular Atrial Fibrillation Concurrently Taking Direct Oral Anticoagulants and Antidepressants
2022
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Chang, K., Chang, K., Chen, C., Chen, C., Wang, C., & Wang, C. (2022). Major Bleeding Risk in Patients With Non-valvular Atrial Fibrillation Concurrently Taking Direct Oral Anticoagulants and Antidepressants. doi.org. https://doi.org/10.3389/fnagi.2022.791285

Association between concomitant use of direct oral anticoagulants with antidepressants and an increased risk of hemorrhage: analysis of the food and drug administration adverse event reporting system database.
2026
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Y, R., Y, Z., Y, C., & H, L. (2026). Association between concomitant use of direct oral anticoagulants with antidepressants and an increased risk of hemorrhage: analysis of the food and drug administration adverse event reporting system database.. doi.org. https://doi.org/10.3389/fmed.2026.1765791

Bleeding risk between newer direct-acting oral anticoagulants and selective serotonin reuptake inhibitors. Case report and literature review
2021
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Higueras, T. G., Cortés, F. C., Alonso, S. S. D. L. C., & Forés, S. V. (2021). Bleeding risk between newer direct-acting oral anticoagulants and selective serotonin reuptake inhibitors. Case report and literature review. doi.org. https://doi.org/10.1192/j.eurpsy.2021.1293

Pharmacovigilance Analysis of Bleeding Events Associated With Selective Serotonin Reuptake Inhibitors (SSRIs) Using the US Food and Drug Administration Adverse Event Reporting System (FAERS).
2026
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ACY, C. (2026). Pharmacovigilance Analysis of Bleeding Events Associated With Selective Serotonin Reuptake Inhibitors (SSRIs) Using the US Food and Drug Administration Adverse Event Reporting System (FAERS).. doi.org. https://doi.org/10.7759/cureus.110163

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