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MDMA-assisted therapy reduces anxiety symptoms in adults.

the verdict
CONTESTED PARTIAL
Recorded sources
6 sources for · 1 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that MDMA-assisted therapy reduces anxiety symptoms in adults?

Partly. Several sources indicate MDMA-assisted therapy may reduce anxiety, but the strongest evidence concerns PTSD symptom severity rather than anxiety in adults generally; a Cochrane review rates the MDMA anxiety effect as very uncertain, and one protocol notes transient anxiety increases during treatment.

Verdict: CONTESTED PARTIAL · 6 sources for, 1 against · Last checked

The private library was unavailable for some searches in this check. Missing library results are not evidence against the claim.

Evidence for · 6
MDMA-assisted psychotherapy
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MDMA-assisted psychotherapy. (n.d.). en.wikipedia.org. https://en.wikipedia.org/wiki/MDMA-assisted_psychotherapy

Evidence against · 1
Social anxiety and MDMA-assisted therapy investigation: a novel clinical trial protocol -
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Social anxiety and MDMA-assisted therapy investigation: a novel clinical trial protocol - PMC Lock. (n.d.). pmc.ncbi.nlm.nih.gov. https://doi.org/10.3389/fpsyt.2023.1083354

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More for · 5
Effects of MDMA-assisted therapy for PTSD on self-experience
2024
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Kolk, B. A. v. d., Wang, J. B., Yehuda, R., Bedrosian, L., Coker, A. R., & Harrison, C. (2024). Effects of MDMA-assisted therapy for PTSD on self-experience. doi.org. https://doi.org/10.1371/journal.pone.0295926

Therapeutic Alliance and Perceived Closeness in MDMA-Assisted Therapy for Social Anxiety Disorder
2026
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Diehl, J. M., Chwyl, C., Kennedy, L., Lejeune, J., & Luoma, J. B. (2026). Therapeutic Alliance and Perceived Closeness in MDMA-Assisted Therapy for Social Anxiety Disorder. doi.org. https://doi.org/10.31234/osf.io/tezgw_v1

Psychedelic-assisted therapy for treating anxiety, depression, and existential distress in people with life-threatening diseases.
2024
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S, S., K, N., Y, S., V, P., M, L., Y, B., G, S., & C, B. (2024). Psychedelic-assisted therapy for treating anxiety, depression, and existential distress in people with life-threatening diseases.. doi.org. https://doi.org/10.1002/14651858.cd015383.pub2

MDMA-assisted therapy and current treatment options for chronic, treatment-resistant, moderate or higher severity post-traumatic stress disorder: Systematic literature review
2025
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Stanicic, F., Zah, V., Grbic, D., Vukicevic, D., & Angelo, D. d. (2025). MDMA-assisted therapy and current treatment options for chronic, treatment-resistant, moderate or higher severity post-traumatic stress disorder: Systematic literature review. doi.org. https://doi.org/10.1371/journal.pone.0327778

MDMA-Assisted Psychotherapy for Treatment of Posttraumatic Stress Disorder: A Systematic Review With Meta-Analysis.
2022
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Smith, K. W., Sicignano, D. J., Hernandez, A. V., & White, C. M. (2022). MDMA-Assisted Psychotherapy for Treatment of Posttraumatic Stress Disorder: A Systematic Review With Meta-Analysis.. doi.org. https://doi.org/10.1002/jcph.1995

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