Loperamide can interact with certain prescription drugs.

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Loperamide can interact with certain prescription drugs?

Yes. Loperamide is known to interact with certain prescription drugs, particularly cytochrome P450 and P-glycoprotein inhibitors, which can significantly alter its pharmacokinetics and toxicity profile.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked 4 Oct 2026

The analysis

The claim is specific and empirically verifiable. Retrieved papers 0 and 7 explicitly examine and model how loperamide interacts with transporter proteins and prescription drug inhibitors (such as quinidine, ritonavir, and itraconazole), confirming the claim.

Evidence for · 2

Interaction of Morphine, Fentanyl, Sufentanil, Alfentanil, and Loperamide with the Efflux Drug Transporter P-glycoprotein

2002

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Wandel, C., Kim, R., Wood, M., & Wood, A. (2002). Interaction of Morphine, Fentanyl, Sufentanil, Alfentanil, and Loperamide with the Efflux Drug Transporter P-glycoprotein. doi.org. https://doi.org/10.1097/00000542-200204000-00019

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More for · 1

Managing Drug-Drug Interactions Involving the Non-Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling.

2026

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Z, Z., GR, A., M, L., J, D., MJ, Z., P, Z., & MF, P. (2026). Managing Drug-Drug Interactions Involving the Non-Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling.. doi.org. https://doi.org/10.1002/psp4.70148

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