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the claim

Myostatin negatively regulates skeletal muscle growth in animals.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Myostatin negatively regulates skeletal muscle growth in animals?

Yes. Extensive scientific literature confirms that myostatin acts as a negative regulator of skeletal muscle growth, with its inhibition or genetic knockout consistently leading to significant muscle hypertrophy across multiple species.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The analysis

Multiple retrieved papers explicitly describe myostatin (GDF-8) as a negative regulator of skeletal muscle growth, citing both genetic knockouts and pharmacological inhibition studies where blocking myostatin leads to increased muscle mass.

Evidence for · 5
L-ornithine-L-aspartate enhances protein anabolism and growth performance in broilers by modulating the liver-NH<sub>3</sub>/Gln-muscle axis.
2026
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X, Z., G, M., B, W., & Y, G. (2026). L-ornithine-L-aspartate enhances protein anabolism and growth performance in broilers by modulating the liver-NH<sub>3</sub>/Gln-muscle axis.. doi.org. https://doi.org/10.1016/j.jare.2026.05.045

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More for · 4
Targeting Myostatin for Sustainable Meat Production: Insights From Multiple Species.
2026
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C, S., F, P., D, C., S, B., MF, T., M, P., S, C., IL, H., K, P., & E, L. (2026). Targeting Myostatin for Sustainable Meat Production: Insights From Multiple Species.. doi.org. https://doi.org/10.1002/age.70149

Genetic and Pharmacologic Inhibition of Myostatin Restores Muscle Mass in a Dynamin 2-Related Centronuclear Myopathy Mouse Model.
2026
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D, A., A, D., V, M., A, V., P, C., D, Q., K, E., C, S., G, E., C, L., G, A., C, J., P, A., B, M., M, B., H, C., L, S., R, O., B, M., M, R., & F, D. (2026). Genetic and Pharmacologic Inhibition of Myostatin Restores Muscle Mass in a Dynamin 2-Related Centronuclear Myopathy Mouse Model.. doi.org. https://doi.org/10.1002/jcsm.70338

Myostatin Signaling in Skeletal Muscle: Implications for Athletic Performance.
2026
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S, C., D, U., M, I., DH, R., Z, S., B, G., A, N., J, M., A, W., & B, V. (2026). Myostatin Signaling in Skeletal Muscle: Implications for Athletic Performance.. doi.org. https://doi.org/10.1002/cph4.70190

Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy.
2026
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DHC, N., M, E., & RCI, W. (2026). Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy.. doi.org. https://doi.org/10.1113/ep093732

What does the evidence say?

Multiple retrieved papers explicitly describe myostatin (GDF-8) as a negative regulator of skeletal muscle growth, citing both genetic knockouts and pharmacological inhibition studies where blocking myostatin leads to increased muscle mass.

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