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the claim

HIV requires the CCR5 coreceptor to infect human T cells.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that HIV requires the CCR5 coreceptor to infect human T cells?

Yes. Multiple studies substantiate that HIV relies on the CCR5 coreceptor to infect target human cells.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the well-established virological fact that HIV-1 utilizes the CCR5 coreceptor for cellular entry, alongside CD4.

Evidence for · 4
Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry
1997
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Moriuchi, H., Moriuchi, M., & Fauci, A. S. (1997). Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry. doi.org. https://doi.org/10.4049/jimmunol.159.11.5441

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More for · 3
Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies
2022
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Weichseldorfer, M., Tagaya, Y., Reitz, M., DeVico, A. L., & Latinovic, O. S. (2022). Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies. doi.org. https://doi.org/10.1186/s12967-022-03243-8

CCR5 as a Therapeutic Target in HIV Disease: From CRISPR/Cas9 Gene Editing to Maraviroc-Mediated Inhibition.
2026
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U, I., K, K., M, S., Y, Y., & RE, S. (2026). CCR5 as a Therapeutic Target in HIV Disease: From CRISPR/Cas9 Gene Editing to Maraviroc-Mediated Inhibition.. doi.org. https://doi.org/10.3390/v18090972

Quantifying the Sensitivity of HIV-1 Viral Entry to Receptor and Coreceptor Expression
2018
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Mistry, B., D'Orsogna, M. R., Webb, N. E., Lee, B., & Chou, T. (2018). Quantifying the Sensitivity of HIV-1 Viral Entry to Receptor and Coreceptor Expression. arxiv.org. https://doi.org/10.1021/acs.jpcb.6b02102

What does the evidence say?

The retrieved literature consistently supports the well-established virological fact that HIV-1 utilizes the CCR5 coreceptor for cellular entry, alongside CD4.

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