Tinnitus is generated by aberrant neural activity in the auditory pathway
the verdict
SUPPORTED
the evidence backs this
confidence 75/100
Extensive neurophysiological and neuroimaging evidence demonstrates that tinnitus is driven by maladaptive plastic changes in the central auditory pathway, characterized by aberrant spontaneous firing rates, neural hyperactivity, and pathological synchrony.
Evidence for · 12
Modelling homeostatic plasticity in the auditory cortex results in neural signatures of tinnitus
2022 · cited by 0
Paper 0 models homeostatic plasticity in the auditory cortex, showing that increased neural noise and firing rates serve as signatures of tinnitus.
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More for · 11
Maladaptive plasticity in tinnitus--triggers, mechanisms and treatment.
2016 · cited by 0
Paper 1 reviews maladaptive neural plasticity resulting in increased spontaneous firing rates and synchrony within central auditory structures.
Maladaptive neural synchrony in tinnitus: origin and restoration.
2015 · cited by 0
Paper 2 links tinnitus to aberrant neural synchrony and delta-band activity generated by deafferented auditory networks.
Role of auditory cortex in noise- and drug-induced tinnitus.
2008 · cited by 0
Paper 3 describes tinnitus as the result of pathologically increased synchrony and activation within interconnected auditory neural assemblies.
Tinnitus and auditory cortex: using adapted functional near-infrared spectroscopy to measure resting-state functional connectivity.
2021 · cited by 0
Paper 4 uses neuroimaging to show that tinnitus arises from aberrant hyperactivation and increased resting-state functional connectivity within the auditory cortex.
Central tinnitus.
2003 · cited by 0
Paper 5 explains that hearing loss reduces lateral inhibition, inducing hypersensitivity, hyperactivity, and altered tonotopic maps in central auditory levels.
Correlated neural activity as the driving force for functional changes in auditory cortex.
2007 · cited by 0
Paper 6 demonstrates that correlated neural activity and hypersynchrony drive functional changes and reorganization in the auditory cortex underlying tinnitus.
Tinnitus-related increases in single-unit activity in awake rat auditory cortex correlate with tinnitus behavior.
2024 · cited by 0
Paper 7 finds that rats with behavioral evidence of tinnitus exhibit significant increases in spontaneous, sound-evoked, and bursting activity in primary auditory cortex.
Neural mechanisms underlying somatic tinnitus.
2007 · cited by 0
Paper 8 shows that bimodal somatosensory integration modulates firing rates and synchrony in dorsal cochlear nucleus neurons, correlating with somatic tinnitus.
Tinnitus: Models and mechanisms.
2011 · cited by 0
Paper 9 synthesizes evidence that tinnitus stems from excitatory and inhibitory imbalances causing hyperactivity, bursting discharges, and neural synchrony.
Descending auditory system/cerebellum/tinnitus.
1999 · cited by 0
Paper 10 discusses how aberrant auditory stimuli and tinnitus influence the activity and function of the descending auditory system.
Neuroanatomy of tinnitus.
1999 · cited by 0
Paper 11 concludes that tinnitus is central in origin, arising from plastic transformations and excessive spontaneous activity in the central auditory system.